379 Result(s)
within
**-Lin Wang
Life Sciences
Animal Genetics and Genomics
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Article
Temporal and spatial expression of biologically active human factor VIII in the milk of transgenic mice driven by mammary-specific bovine α-lactalbumin regulation sequences
Hemophilia A is one of the major inherited bleeding disorders caused by a deficiency or abnormality in coagulation factor VIII (FVIII). Hemophiliacs have been treated with whole plasma or purified FVIII concen...
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Article
Genetic relationships among twelve Chinese indigenous goat populations based on microsatellite analysis
Twelve Chinese indigenous goat populations were genotyped for twenty-six microsatellite markers recommended by the EU Sheep and Goat Biodiversity Project. A total of 452 goats were tested. Seventeen of the 26 ...
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Article
The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigree
A canine integrated linkage-radiation map has been recently constructed by using microsatellite markers. This map, with a good coverage of the canine genome, allows for a genome-wide search for the extent and ...
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Article
Open AccessGenetic variation and relationships of eighteen Chinese indigenous pig breeds
Chinese indigenous pig breeds are recognized as an invaluable component of the world's pig genetic resources and are divided traditionally into six types. Twenty-six microsatellite markers recommended by the F...
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Article
Open AccessMultivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches
Current statistical methods for sib-pair linkage analysis of complex diseases include linear models, generalized linear models, and novel data mining techniques. The purpose of this study was to further invest...
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Article
Isolation and characterization of microsatellite loci in Acrossocheilus paradoxus (Cyprinidae) using PCR-based isolation of microsatellite arrays (PIMA)
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Article
Predicted ATP-binding cassette systems in the phytopathogenic mollicute Spiroplasma kunkelii
Spiroplasma kunkelii is a cell wall-free, helical, and motile mycoplasma-like organism that causes corn stunt disease in maize. The bacterium has a compact genome with a gene set approac...
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Article
Transgenic tomato plants expressing the Arabidopsis NPR1 gene display enhanced resistance to a spectrum of fungal and bacterial diseases
Development of effective disease-resistance to a broad-range of pathogens in crops usually requires tremendous resources and effort when traditional breeding approaches are taken. Genetic engineering of diseas...
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Article
Open AccessMolecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)
Severe acute respiratory syndrome (SARS), a recent epidemic human disease, is caused by a novel coronavirus (SARS-CoV). First reported in Asia, SARS quickly spread worldwide through international travelling. A...
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Genetic and physical map** of Pi36(t), a novel rice blast resistance gene located on rice chromosome 8
Blast resistance in the indica cultivar (cv.) Q61 was inherited as a single dominant gene in two F2 populations, F2-1 and F2-2, derived from crosses between the donor cv. and two susceptible japonica cvs. Aichi A...
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Article
The Mutually Exclusive Flip and Flop Exons of AMPA Receptor Genes Were Derived from an Intragenic Duplication in the Vertebrate Lineage
The incomplete correlation between the organismal complexities and the number of genes among eukaryotic organisms can be partially explained by multiple protein products of a gene created by alternative splici...
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Article
Open AccessAnalysis of 10,000 ESTs from lymphocytes of the cynomolgus monkey to improve our understanding of its immune system
The cynomolgus monkey (Macaca fascicularis) is one of the most widely used surrogate animal models for an increasing number of human diseases and vaccines, especially immune-system-related ones. Towards a better ...
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Article
A new cell line from larval fat bodies of the bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae)
A new cell line, designated IOZCAS-Ha-I, was initiated from the fat body of larvae of Helicoverpa armigera (Lepidoptera: Noctuidae) in TNM-FH medium containing 10% fetal bovine serum. Spherical cells were predomi...
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Article
Open AccessIdentification of rat lung-specific microRNAs by microRNA microarray: valuable discoveries for the facilitation of lung research
An important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid a...
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Article
Open AccessConiferEST: an integrated bioinformatics system for data reprocessing and mining of conifer expressed sequence tags (ESTs)
With the advent of low-cost, high-throughput sequencing, the amount of public domain Expressed Sequence Tag (EST) sequence data available for both model and non-model organism is growing exponentially. While t...
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Article
Open AccessComplete sequence and organization of Antheraea pernyi nucleopolyhedrovirus, a dr-rich baculovirus
The completion and reporting of baculovirus genomes is extremely important as it advances our understanding of gene function and evolution. Due to the large number of viral genomes now sequenced it is very imp...
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Article
Rapid Evolution, Genetic Variations, and Functional Association of the Human Spermatogenesis-Related Gene NYD-SP12
NYD-SP12 is a recently identified spermatogenesis-related gene with a pivotal role in human testis development. In this study, we analyzed between-species divergence and within-species va...
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Article
Open AccessGlobal transcription profiling reveals differential responses to chronic nitrogen stress and putative nitrogen regulatory components in Arabidopsis
A large quantity of nitrogen (N) fertilizer is used for crop production to achieve high yields at a significant economic and environmental cost. Efforts have been directed to understanding the molecular basis ...
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Article
Open AccessUnravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering
It becomes increasingly clear that our current taxonomy of clinical phenotypes is mixed with molecular heterogeneity. Of vital importance for refined clinical practice and improved intervention strategies is t...
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Open AccessAn optimized procedure greatly improves EST vector contamination removal
The enormous amount of sequence data available in the public domain database has been a gold mine for researchers exploring various themes in life sciences, and hence the quality of such data is of serious con...
