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Imaging surface structure and premelting of ice Ih with atomic resolution
Ice surfaces are closely relevant to many physical and chemical properties, such as melting, freezing, friction, gas uptake and atmospheric reaction1–8. Despite extensive experimental and theoretical investigatio...
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Open AccessA longitudinal resource for population neuroscience of school-age children and adolescents in China
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The develop...
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Open AccessVirus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals
Wildlife is reservoir of emerging viruses. Here we identified 27 families of mammalian viruses from 1981 wild animals and 194 zoo animals collected from south China between 2015 and 2022, isolated and characte...
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Open AccessMultilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer
Diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC) are the major histological types of gastric cancer (GC). The molecular mechanism underlying DGC and IGC differences are poorly underst...
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Article
Open AccessFluorescent porous organic polymers for detection and adsorption of nitroaromatic compounds
A fluorescent porous organic polymer (FPOP) with strong fluorescence and tunable emission colors, was synthesized through a simple cost-effective method via Scholl coupling reaction. Experiments proved the sta...
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Open AccessVarying climatic-social-geographical patterns shape the conflict risk at regional and global scales
Given that armed conflict has been seriously impeding sustainable development, reducing the frequency and intensity of armed conflicts has become an explicit goal and a common theme of the 2030 Sustainable Dev...
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Open AccessShort term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China
With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...
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Open AccessModelling armed conflict risk under climate change with machine learning and time-series data
Understanding the risk of armed conflict is essential for promoting peace. Although the relationship between climate variability and armed conflict has been studied by the research community for decades with q...
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Open AccessThe induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression
Despite the remarkable success of immunotherapy in many types of cancer, pancreatic ductal adenocarcinoma has yet to benefit. Innate immune cells are critical to anti-tumor immunosurveillance and recent studie...
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Open AccessmiR-181c-5p mediates apoptosis of vascular endothelial cells induced by hyperoxemia via ceRNA crosstalk
Oxygen therapy has been widely used in clinical practice, especially in anesthesia and emergency medicine. However, the risks of hyperoxemia caused by excessive O2 supply have not been sufficiently appreciated. B...
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Open AccessAntibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the development of effective therapeutics and vaccines. We recently isolated a large number of monoclonal antibodies from S...
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Article
Action of a minimal contractile bactericidal nanomachine
R-type bacteriocins are minimal contractile nanomachines that hold promise as precision antibiotics1–4. Each bactericidal complex uses a collar to bridge a hollow tube with a contractile sheath loaded in a metast...
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Open AccessDeletion of exon 4 in LAMA2 is the most frequent mutation in Chinese patients with laminin α2-related muscular dystrophy
Although recessive mutations in LAMA2 are already known to cause laminin α2-related muscular dystrophy, a rare neuromuscular disorder, large deletions or duplications within this gene are not well-characterized. ...
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Article
Open AccessGene expression profiles of germ-free and conventional piglets from the same litter
Germ-free (GF) pigs have clear microbiological backgrounds, and are extensively used as large animal models in the biomedical sciences. However, investigations of the transcriptomic differences between GF and ...
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Article
Open AccessA proteomics landscape of circadian clock in mouse liver
As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a transcription factor (TF) ...
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Open AccessOutcomes of adjuvant epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) treatment for EGFR-mutant non-small-cell lung cancer: a propensity-score analysis
Small molecule tyrosine kinase inhibitors (TKIs) have transformed the management of advanced non-small-cell lung cancer (NSCLC) harboring activating epithelial growth factor receptor (EGFR) mutations, while th...
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Open AccessCurcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines
Inhibitory A type γ-aminobutyric acid receptors (GABAARs) play a pivotal role in orchestrating various brain functions and represent an important molecular target in neurological and psychiatric diseases, necessi...
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Article
Open AccessPotential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility
The gut microbiota is involved in various physiological functions, and disturbances in the host-microbiome have been proven to contribute to the dysfunction of gut; however, whether microbiota participates in ...
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Article
Correction: Corrigendum: Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation
Nature Communications 5: Article number: 3986 (2014); Published 9 June 2014; Updated 11 April 2016 The financial support for this Article was not fully acknowledged. The Acknowledgements should have included t...
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Open AccessDifferent neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats
Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little is known about their mechanism. ...