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Article
Dysfunction of GABAergic neurons in the parafacial zone mediates sleep disturbances in a streptozotocin-induced rat model of sporadic Alzheimer’s disease
Sleep disturbances are prevalent among patients with Alzheimer’s disease (AD) and often precede the onset and progression of dementia. However, there are no reliable animal models for investigating sleep distu...
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Article
Open AccessCa2+ in the dorsal raphe nucleus promotes wakefulness via endogenous sleep-wake regulating pathway in the rats
Serotonergic neurons in the dorsal raphe nucleus (DRN) are involved in the control of sleep-wake states. Our previous studies have indicated that calcium (Ca2+) modulation in the DRN plays an important role in ra...
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Article
Open AccessDifferent neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats
Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little is known about their mechanism. ...
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Article
Involvement of adrenoceptors, dopamine receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice
7-O-ethylfangchinoline (YH-200) is a bisbenzylisoquinoline derivative. The aim of this study was to investigate the antidepressant-like action and underlying mechanisms of YH-200 in mice.
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Article
Open AccessGlucocorticoid receptors in the locus coeruleus mediate sleep disorders caused by repeated corticosterone treatment
Stress induced constant increase of cortisol level may lead to sleep disorder, but the mechanism remains unclear. Here we described a novel model to investigate stress mimicked sleep disorders induced by repet...
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Article
Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats
Disrupted sleep may be a prodromal symptom or a predictor of depressive disorders. In this study we investigated the relationship between depression symptoms and disrupted sleep using a novel model of stress-m...
