835 Result(s)

Article

Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling

O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic post-translational modification (PTM) involving the covalent binding of serine and/or threonine residues, which regulates bone c...

Shengqian Li, Wenhao Ren, **g**g Zheng, Shaoming Li… in Cell Communication and Signaling (2024)

Article

Correction: Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis

Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, ** Ling… in Cell Death & Disease (2024)

Article

Tudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP

The neonatal mammalian heart exhibits considerable regenerative potential following injury through cardiomyocyte proliferation, whereas mature cardiomyocytes withdraw from the cell cycle and lose regenerative ...

Chao Su, **zheng Ma, Xuyang Yao, Wei Hao, Shihu Gan… in Cell Communication and Signaling (2024)

Article

Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity

Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under these conditions and the transcriptional differences between dif...

Feng-Min Zhang, Hao-Fan Wu, Ke-Fan Wang, Ding-Ye Yu… in Cell Death & Disease (2024)

Article

Dexmedetomidine improves the circulatory dysfunction of the glymphatic system induced by sevoflurane through the PI3K/AKT/ΔFosB/AQP4 pathway in young mice

Multiple sevoflurane exposures may damage the develo** brain. The neuroprotective function of dexmedetomidine has been widely confirmed in animal experiments and human studies. However, the effect of dexmede...

Shuying Wang, **ao** Yu, Lili Cheng, Weishu Ren, Gehua Wen, Xue Wu… in Cell Death & Disease (2024)

Article

Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression

Triple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breast cancer. A high circulating neutrophil-to-lymphocyte ratio (NLR) is strongly linked to...

Chenghui Yang, Lili Li, Zhiqiang Ye, Anqi Zhang… in Cell Communication and Signaling (2024)

Article

Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...

Chunming Xu, Jie Wu, Jiye Ye, Yuancheng Si, **shi Zhang, Bowen Wu… in Cell Death & Disease (2024)

Article

Correction to: Pum2-Mff axis fine-tunes mitochondrial quality control in acute ischemic kidney injury

** Wang, **jun Zhu, Sam Toan, Ruibing Li, Jun Ren… in Cell Biology and Toxicology (2024)

Article

Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway

Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms that underlie this phenomenon have yet to be extensively investigated. The Morris w...

Hongxia Li, Wenlan Pan, Chenqi Li, Mengyu Cai, Wen**g Shi… in Cell Death Discovery (2024)

Article

An oncogenic role of lncRNA SNHG1 promotes ATG7 expression and autophagy involving tumor progression and sunitinib resistance of Renal Cell Carcinoma

Renal cell carcinoma (RCC) is a malignant tumor with high incidence in adult kidney. Long non-coding RNAs (lncRNAs) have recently been recognized as important regulators in the development of RCC. However, whe...

Pei Tian, **xing Wei, **g Li, Junkai Ren, Chaohong He in Cell Death Discovery (2024)

Article

Biomechanical properties of articular cartilage in different regions and sites of the knee joint: acquisition of osteochondral allografts

Osteochondral allograft (OCA) transplantation involves grafting of natural hyaline cartilage and supporting subchondral bone into the cartilage defect area to restore its biomechanical and tissue structure. Ho...

Yongsheng Ma, Qitai Lin, Xueding Wang, Yang Liu, … in Cell and Tissue Banking (2024)

Article

NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1

Ovarian endometriosis is a common gynecological disease, and one of its most significant symptoms is infertility. In patients with endometriosis, defects in endometrial decidualization lead to impaired endomet...

Mengxue Wang, Fangyuan Sun, Shucai Zhang… in Cellular and Molecular Life Sciences (2024)

Article

O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology

O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational modification (PTM) of cytoplasmic and nuclear proteins. O-GlcNAcylation levels are regulated by t...

**aohan Yan, **g**g Zheng, Wenhao Ren, Shaoming Li… in Cell Communication and Signaling (2024)

Article

Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure

Oxidative stress is implicated in the pathogenesis of heart failure. Dual oxidase 1 (DUOX1) might be important in heart failure development through its mediating role in oxidative stress. This study was design...

Yan Song Li, **gwen **a, Chang Yuan Chen, Shu Hong Ren… in BMC Molecular and Cell Biology (2024)

Article

Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer

Single cell RNA sequencing (scRNA-seq), a powerful tool for studying the tumor microenvironment (TME), does not preserve/provide spatial information on tissue morphology and cellular interactions. To understan...

**g **ao, **nyang Yu, Fanlin Meng, Yuncong Zhang, Wenbin Zhou… in Cell Death & Disease (2024)

Article

The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia

Acute myeloid leukemia (AML) with mixed-lineage leukemia (MLL) gene rearrangements (MLL-r) is an aggressive subtype of blood cancer with dismal prognosis, underscoring the urgent need for novel therapeutic strate...

Wenqi Wu, Yanan Jiang, Donghui **ng, Yixin Zhai, Huimeng Sun… in Cell Death Discovery (2024)

Article

Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs

CRISPR-Cas systems and IS200/IS605 transposon-associated TnpBs have been utilized for the development of genome editing technologies. Using bioinformatics analysis and biochemical experiments, here we present ...

Kuan Ren, Fengxia Zhou, Fan Zhang, Mingyu Yin, Yuwei Zhu, Shouyu Wang… in Cell Research (2024)

Article

The crosstalk between mitochondrial quality control and metal-dependent cell death

Mitochondria are the centers of energy and material metabolism, and they also serve as the storage and dispatch hubs of metal ions. Damage to mitochondrial structure and function can cause abnormal levels and ...

Qi-yuan Zhou, Chao Ren, **g-yan Li, Lu Wang, Yu Duan, Ren-qi Yao… in Cell Death & Disease (2024)

Article

PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiation

Paired box 1 (PAX1) is a transcription factor and essential for the development of pharyngeal pouches-derived tissues, including thymus. PAX1 mutations are identified in Severe Combined Immunodeficiency (SCID)...

Danxiu Miao, Jie Ren, Yanhan Jia, Yihui Jia, Yanshu Li… in Cell Communication and Signaling (2024)

Article

FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression

FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the functions and the molecular mechanisms regulated by FBXO32 in lung a...

Jie Wu, Ting Wen, Antonio Marzio, Dingli Song, Sisi Chen… in Cell Death & Disease (2024)