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Article
Open AccessEffect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury
Diabetic cardiomyopathy (DCM) is a chronic disease caused by diabetes mellitus, which is recognized as a worldwide challenging disease. This study aimed to investigate the role and the potential mechanism of k...
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Article
Open AccessEstablishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1
Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to understanding the underlying mechanisms of resistance and devel...
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Article
Open AccessThe maternal drug exposure birth cohort (DEBC) in China
Drug exposure during pregnancy lacks global fetal safety data. The maternal drug exposure birth cohort (DEBC) study, a prospective longitudinal investigation, aims to explore the correlation of maternal drug e...
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Article
Open AccessLanthanide-regulating Ru-O covalency optimizes acidic oxygen evolution electrocatalysis
Precisely modulating the Ru-O covalency in RuOx for enhanced stability in proton exchange membrane water electrolysis is highly desired. However, transition metals with d-valence electrons, which were doped into ...
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Article
Open AccessAssociation between Life’s Essential 8 and cataract among US adults
Currently, a comprehensive assessment of the relationship between ideal cardiovascular health (CVH) indicators and cataract risk is lacking. Life’s Essential 8 (LE8) is the latest concept proposed by the Ameri...
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Article
Open AccessComplete chloroplast genome structural characterization of two Aerides (Orchidaceae) species with a focus on phylogenetic position of Aerides flabellata
The disputed phylogenetic position of Aerides flabellata Rolfe ex Downie, due to morphological overlaps with related species, was investigated based on evidence of complete chloroplast (cp) genomes. The structura...
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Open AccessThe first ensemble of kilometer-scale simulations of a hydrological year over the third pole
An accurate understanding of the current and future water cycle over the Third Pole is of great societal importance, given the role this region plays as a water tower for densely populated areas downstream. An...
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Article
Open AccessTrajectories and predictors of emotional exhaustion in clinical nurses in the context of healthcare crisis: a case study in **’an, China
This study investigated the growth trajectory of emotional exhaustion and its predictors in clinical nurses in the context of healthcare crisis in the post pandemic era. A total of 422 Chinese clinical nurses ...
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Open AccessVulnerable conditions syndemic, depression, and suicidal ideation among school children in China: cross-sectional census findings
Mental health issues (depression and suicidal ideation) are increasingly common in children and emerge as escalating public health concerns. The syndemics that underline the importance of risk factor clusterin...
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Open AccessmPPTMP195 nanoparticles enhance fracture recovery through HDAC4 nuclear translocation inhibition
Delayed repair of fractures seriously impacts patients’ health and significantly increases financial burdens. Consequently, there is a growing clinical demand for effective fracture treatment. While current ma...
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Open AccessAuthor Correction: Magnetic breakdown and spin-zero effect in quantum oscillations in kagome metal CsV3Sb5
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Article
Open AccessMolecular characterization and induced changes of histone acetyltransferases in the tick Haemaphysalis longicornis in response to cold stress
Epigenetic modifications of histones play important roles in the response of eukaryotic organisms to environmental stress. However, many histone acetyltransferases (HATs), which are responsible for histone ace...
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Article
Open AccessCharacterizing human postprandial metabolic response using multiway data analysis
Analysis of time-resolved postprandial metabolomics data can improve our understanding of the human metabolism by revealing similarities and differences in postprandial responses of individuals. Traditional da...
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Article
Open AccessGenetic analysis of the causal relationship between gut microbiota and intervertebral disc degeneration: a two-sample Mendelian randomized study
Several recent studies have reported a possible association between gut microbiota and intervertebral disc degeneration; however, no studies have shown a causal relationship between gut microbiota and disc deg...
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Open AccessAn individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma
Pediatric papillary thyroid carcinomas (PPTCs) exhibit high inter-tumor heterogeneity and currently lack widely adopted recurrence risk stratification criteria. Hence, we propose a machine learning-based objec...
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Article
Open AccessA novel multidrug-resistant cell line from a Chinese patient with pancreatic ductal adenocarcinoma
Chemotherapy resistance poses clinical challenges in pancreatic cancer treatment. Develo** cell lines resistant to chemotherapy is crucial for investigating drug resistance mechanisms and identifying alterna...
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Article
Open AccessConstruction and application of the core competence course training system for infectious disease specialist nurses
This study aims to construct and apply a training course system which was scientific and comprehensive to foster the core competence of infectious disease specialist nurses.
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Article
Open AccessRecent advances, challenges, and perspectives on carbon capture
Carbon capture, utilization and storage (CCUS) technologies play an essential role in achieving Net Zero Emissions targets. Considering the lack of timely reviews on the recent advancements in promising CCUS t...
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Article
Open AccessThe long-term cost-effectiveness of once-weekly semaglutide versus sitagliptin for the treatment of type 2 diabetes in China
To estimate the long-term cost-effectiveness of once-weekly semaglutide versus sitagliptin as an add-on therapy for type 2 diabetes patients inadequately controlled on metformin in China, to better inform heal...
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Open AccessAn IoT-based low-cost architecture for smart libraries using SDN
In the evolving landscape of smart libraries, this research pioneers an IoT-based low-cost architecture utilizing Software-Defined Networking (SDN). The increasing demand for more efficient and economical solu...
