1,103 Result(s)
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**** Chu
English
Biomedicine, general
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Article
Open AccessTelomere-to-telomere Citrullus super-pangenome provides direction for watermelon breeding
To decipher the genetic diversity within the cucurbit genus Citrullus, we generated telomere-to-telomere (T2T) assemblies of 27 distinct genotypes, encompassing all seven Citrullus species. This T2T super-pangeno...
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Open AccessA randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma (SOCRATES HCC)
Therapeutic options for early-stage hepatocellular carcinoma (HCC) in individual patients can be limited by tumor and location, liver dysfunction and comorbidities. Many patients with early-stage HCC do not re...
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Open AccessClinical applications of telemedicine services using a regional telemedicine platform for cancer treatment: a cross-sectional study
Telemedicine is beneficial for improving treatment efficiency and reducing medical expenses of cancer patients. This study focuses on cancer patients participating in teleconsultations through a regional telem...
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Article
Integration of apaQTL and eQTL analysis reveals novel SNPs associated with occupational pulmonary fibrosis risk
To explore the association between apaQTL/eQTL-SNPs and the susceptibility to silicosis. A silicosis-related GWAS was initially conducted to screen for single nucleotide polymorphisms (SNPs) associated with th...
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Article
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility
Tobacco carcinogens metabolism-related genes (TCMGs) could generate reactive metabolites of tobacco carcinogens, which subsequently contributed to multiple diseases. However, the association between genetic va...
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Article
Surface-derived phosphate layer on NiFe-layered double hydroxide realizes stable seawater oxidation at the current density of 1 A°cm−2
Seawater electrolysis, especially in coastlines, is widely considered as a sustainable way of making clean and high-purity H2 from renewable energy; however, the practical viability is challenged severely by the ...
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Article
High-performance Bi2S3/ZnO photoanode enabled by interfacial engineering with oxyanion for efficient photoelectrochemical water oxidation
In the present contribution, we demonstrate that the sluggish kinetics of oxygen evolution reaction (OER) over the bismuth sulfide (Bi2S3) photoanode, which severely restricts its photoelectrochemical activity, i...
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Examining the impact of the COVID-19 pandemic on homecare services among individuals with traumatic and non-traumatic spinal cord injuries
Descriptive repeated-cross sectional retrospective longitudinal cohort study.
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Article
Open AccessSimulation of functional additive and non-additive genetic effects using statistical estimates from quantitative genetic models
Stochastic simulation software is commonly used to aid breeders designing cost-effective breeding programs and to validate statistical models used in genetic evaluation. An essential feature of the software is...
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Article
Open AccessEnterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis
Enterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The molecular mechanisms involved in EV-A71 pathogenesis have remained el...
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Article
Flurbiprofen microneedle patches for the management of acute postoperative pain
Acute postoperative pain is commonly treated with flurbiprofen (FBP), but conventional delivery methods are suboptimal. This study prepared a new non-burst release microneedles (MNs) using genipin cross-linked...
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Article
Naked-eye visualization of lymph nodes using fluorescence nanoprobes in non-human primate-animal models
Despite sufficient studies performed in non-primate animal models, there exists scanty information obtained from pilot trials in non-human primate animal models, severely hindering nanomaterials moving from ba...
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Article
Open AccessIsorhapontigenin inhibition of basal muscle-invasive bladder cancer attributed to its downregulation of SNHG1 and DNMT3b
Bladder cancer (BC) is among the most prevalent malignant urothelial tumors globally, yet the prognosis for patients with muscle-invasive bladder cancer (MIBC) remains dismal, with a very poor 5-year survival ...
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Article
Open AccessCapturing relationships between suturing sub-skills to improve automatic suturing assessment
Suturing skill scores have demonstrated strong predictive capabilities for patient functional recovery. The suturing can be broken down into several substep components, including needle repositioning, needle entr...
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Article
Open AccessSafety and efficacy of multi-target TKI combined with nivolumab in check-point inhibitor-refractory patients with advanced NSCLC: a prospective, single-arm, two-stage study
Resistance to immune checkpoint inhibitors (ICIs) represents a major unmet medical need in non-small cell lung cancer (NSCLC) patients. Vascular endothelial growth factor (VEGF) inhibition may reverse a suppre...
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Article
Enhancing alkaline water oxidation with NiFe alloy-encapsulated nitrogen-doped vertical graphene array
Advancing efficient and affordable electrocatalysts to boost the oxygen evolution reaction (OER) is pivotal for sustainable green hydrogen production. Herein, we propose the fabrication of nickel-iron alloy na...
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Article
Open AccessUsing the benefit-harm trade-off method to determine the smallest worthwhile effect of intensive motor training on strength for people with spinal cord injury
Interviews using the benefit-harm trade-off method and an online survey.
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Article
Engineering the axial coordination of cobalt single atom catalysts for efficient photocatalytic hydrogen evolution
Improving the catalytic activity of non-noble metal single atom catalysts (SACs) has attracted considerable attention in materials science. Although optimizing the local electronic structure of single atom can...
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Article
Constructing a fluorinated interface layer enriched with Ge nanoparticles and Li-Ge alloy for stable lithium metal anodes
Lithium metal batteries (LMBs) based on metallic Li exhibit high energy density to be competent for advanced energy storage applications. However, the unstable solid electrolyte interphase (SEI) layer due to c...
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Article
Open AccessExamining arterial pulsation to identify and risk-stratify heart failure subjects with deep neural network
Hemodynamic parameters derived from pulse wave analysis have been shown to predict long-term outcomes in patients with heart failure (HF). Here we aimed to develop a deep-learning based algorithm that incorpor...
