37 Result(s)
within
Conference Paper
Yi** **
Metabolic Diseases
Neurosciences
-
Chapter and Conference Paper
Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities
We report an expression and purification procedure to produce homogeneous, active human DP8 and DPIV. The most interesting discovery was that DP8 specifically has both prolyl dipeptidyl aminopeptidase and PEP ...
-
Chapter and Conference Paper
Distribution of Dipeptidyl Peptidase Iv-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR
-
Chapter and Conference Paper
Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y
-
Chapter and Conference Paper
Peptide Substrates of Dipeptidyl Peptidases
-
Chapter and Conference Paper
Dipeptidyl Peptidases and Inflammatory Bowel Disease
-
Chapter and Conference Paper
CD26/DP IV in T Cell Activation and Autoimmunity
In summary, the present study demonstrates a critical role for CD26/DP IV in balancing Th1 immune responses. We observed a deregulation of the autoimmune process in EAE in vitro, the prototypic model of an immune...
-
Chapter and Conference Paper
Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8
-
Chapter and Conference Paper
Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?
Deregulation of DPP-IV-like activity was observed in synovial fluid and blood plasma of patients with RA and PsA. The cellular source of soluble DPP-IV-like enzymatic activity remains unclear.
-
Chapter and Conference Paper
Type-II Transmembrane Prolyl Dipeptidases and Matrix Metalloproteinases in Membrane Vesicles of Active Endothelial Cells
Endothelia cells in sparse culture are migratory and increase the production of gelatinases of serine- and metallo-classes in membrane vesicles. Collectively, proteases associated with membrane vesicles degrad...
-
Chapter and Conference Paper
Structure and Function in Dipeptidyl Peptidase IV and Related Proteins
Potential therapeutic applications of DPIV inhibitors have fuelled interest in understanding the biological roles of DPIV and its relatives. Such efforts are confounded by the ubiquitous expression of DPIV, in...
-
Chapter and Conference Paper
Role of Neuropeptide Y and Dipeptidyl Peptidase IV in Regulation of Ewing’s Sarcoma Growth
-
Chapter and Conference Paper
DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis
The biological significance of the new DPIV family members DP8 and DP9 is unknown. In order to obtain correlations between cell behaviors and peptidase expression levels, DP8 and DP9 overexpression in transfec...
-
Chapter and Conference Paper
Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells
-
Chapter and Conference Paper
Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity
The data presented, demonstrate for the first time PEP turnover of HN by a limited postcysteine as well as the expected post-proline proteolysis demonstrated in cell extract resulting in the inactivation of th...
-
Chapter and Conference Paper
Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM)
Incretin based therapies for type 2 diabetes mellitus are quite promising. Presently, basic research places both GIP and GLP-1 based approaches on an equal standing. Recently, there has been renewed interest i...
-
Chapter and Conference Paper
Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases—Proof of Concept in a Mouse Model of Colitis
In summary these results strongly support the idea that AAPs and DPIV represent a promising target complex for the pharmacological therapy of T cell-mediated diseases by preserving and enhancing endogenous imm...
-
Chapter and Conference Paper
Phosphorus-Containing Inhibitors of Proteolytic Enzymes
-
Chapter and Conference Paper
Possible Role of DP IV Inhibitors in Acne Therapy
The presented data provide evidence that DP IV is expressed on human sebocytes and most likely involved in regulation of sebocyte proliferation and cytokine production. The aminopeptidase inhibitors Lys[Z(NO2)]-t...
-
Chapter and Conference Paper
DPIV/CD26 and FAP in Cancer: A Tale of Contradictions
-
Chapter and Conference Paper
Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling
The DP8 model produced was very similar to the DPIV structure in the α/β hydrolase domain. Analysis of the active site of the DP8 model revealed significant structural conservation in the catalytic triad between ...
