31 Result(s)
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English
Medicine & Public Health
Human Physiology
Metabolic Diseases
Yi** **
Conference Paper
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Chapter and Conference Paper
The Kinetics of Insulin, C-Peptide, and Proinsulin in Normal and Diabetic Man
The accurate measurement of pancreatic insulin secretory rates is the key for our understanding of the hormonal regulation of glucose and other nutrients as well as our insight into the pathophysiology of diab...
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Chapter and Conference Paper
Models for Studying Diabetic Complications
The appeal of using animal models for studying complications of diabetes is their potential to greatly facilitate determination of which of the multiple metabolic, biochemical, and hormonal imbalances associat...
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Chapter and Conference Paper
Mechanisms of Insulin Resistance in Obese and Type II Diabetic Subjects
The decrease biological response to a given level of insulin has been termed insulin resistance. Insulin resistance at the level of target tissues is a characteristic feature of human obesity and type II diabe...
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Chapter and Conference Paper
Metabolic Inhibitors in the Treatment of Diabetes Mellitus
Diabetes mellitus is a heterogenous group of disorders characterised by insulin hyposecretion and insulin insensitivity. Insulin-dependent diabetes mellitus (IDDM) shows predominantly an insulin deficiency whi...
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Chapter and Conference Paper
Why and How to Involve the Diabetic Patient in his Treatment
Doctors are often accused of wanting to keep their patients ignorant and there is truth in the charge. Medicine grew out of magic and it is in the magician’s self-interest to keep his secrets hidden. Medicine ...
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Chapter and Conference Paper
Is Human Insulin Better than Animal Insulin in the Treatment of Insulin-Dependent Diabetes Mellitus?
Studies about human insulin were very limited before 1980, because significant amounts of human insulin could not be obtained. The later development of biosyn-thesis or semisynthesis has allowed large scale te...
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Chapter and Conference Paper
Is it Possible to Prevent Late Complications of Diabetes Mellitus?
There is extensive literature which presents reasonable circumstantial evidence for a relationship between the level of blood glucose and the development of long-term microvascular complications. Evidence is l...
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Chapter and Conference Paper
Particular Aspects of the Management of Diabetes in Children
Children are different and behave differently from adults. They undergo continuous developmental changes both physically and emotionally, and this is reflected in their behavior. Children are not self-sufficie...
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Chapter and Conference Paper
Relationship Between Maternal Glucose Levels and Congenital Malformations in the Infant of the Diabetic Mother
Although there has been considerable improvement in the outcome of pregnancies complicated by diabetes [1–3], the incidence of congenital malformations in infants of diabetic mothers is still three times great...
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Chapter and Conference Paper
What Future for Islet Transplantation in Man?
The idea of transplanting pancreatic islets goes back to Ssobolew [1] and even before 1902 pieces of sheep pancreas were grafted, although without success [2]. With the discovery and introduction of insulin in...
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Chapter and Conference Paper
Role of Abnormal Free Fatty Acid Metabolism in the Pathogenesis and Treatment of Noninsulin-Dependent Diabetes Mellitus
The point of view to be developed in this presentation is based upon the premise that resistance to insulin-stimulated glucose uptake is the basic defect in the majority of patients with noninsulin-dependent d...
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Chapter and Conference Paper
Practicability of Diet in Diabetes Management
As more radical changes are proposed for the diabetic diet, so the practicability of implementing these changes provides an increasing challenge. All forms of lifestyle change are difficult to accomplish, espe...
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Chapter and Conference Paper
Genetics of Diabetes Mellitus
One of the major steps forward in the field was the perception that diabetes mellitus is not an etiologically or pathogenetically uniform disease. All investigations into the genetics of diabetes had been in v...
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Chapter and Conference Paper
Challenging Views on the Pathogenesis of Type I (Insulin-Dependent) Diabetes Mellitus
Evidence accumulated during the past decade has progressively consolidated the concept that type I (insulin-dependent) diabetes is a chronic, destructive, organ-specific autoimmune disorder [1, 2]. In general,...
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Chapter and Conference Paper
Insulin Receptor: Role of Receptor Tyrosine Kinase in Insulin Signalling and Action
Regulation of cellular metabolism and growth by insulin is the result of a series of events initiated by the interaction of the hormone with its cell surface receptors. The insulin receptor structure has been ...
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Chapter and Conference Paper
Physiopathology and Possible Etiology of Hormonal Dysregulations and Insulin Resistance in Obese Rats: a Potential Model for Some Human Obesity
The genetically obese Zucker rat, characterized by the presence of the double recessive gene fa is a model of obesity and insulin resistance. It has a moderate hyperglycemia, and an abnormal oral glucose toleranc...
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Chapter and Conference Paper
Cell Biology of Insulin Action on Glucose Transport and Its Perturbation in Diabetes Mellitus
Glucose entry into cells is key for mammalian survival. Impairment of glucose entry results in a catabolic state marked by hyperglycemia, dehydration and starvation known as diabetes mellitus. The clinical obs...
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Chapter and Conference Paper
Insulin Analogues — Potentials for Improving Diabetes Treatment
Despite many years of clinical experimentation with commercially available short-, intermediate-, and long-acting insulin preparations, good metabolic control is still difficult to attain in a large proportion...
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Chapter and Conference Paper
Inhibitors Influencing Carbohydrate Absorption
Carbohydrates normally represent the majority of the human diet. As mono-, oligo- and, especially, polysaccharides, they form not only the greatest part quantitatively, but also the main energy supply. With a ...
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Chapter and Conference Paper
Advanced Non-Enzymatic Tissue Glycosylation: Biochemical Basis of Late Diabetic Complications
Hyperglycemia can lead to irreversible damage by mediating a number of biochemical or compositional protein alterations. An extensively studied example, increased polyol pathway, results in several metabolic c...
