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Article
CNS-periphery relationships and body weight homeostasis: influence of the glucocorticoid status
The obesity-like effects produced by the chronic intracerebroventricular (i.c.v.) neuropeptide Y (NPY) infusion in normal rats require the presence of glucocorticoids, as none of them occurs when NPY is simila...
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Article
Effects of intravenous neuropeptide Y on insulin secretion and insulin sensitivity in skeletal muscle in normal rats
Intracerebroventricular administration of neuropeptide Y to normal rats induces a syndrome characterised by obesity, hyperinsulinaemia, insulin resistance and over expression of the adipose tissue ob gene. Littl...
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Article
Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinaemia
Neuropeptide Y in the hypothalamus is a potent physiological stimulator of feeding, and may contribute to the characteristic metabolic defects of obesity when hypothalamic levels remain chronically elevated. S...
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Article
Endogenous glucose production, gluconeogenesis and liver glycogen concentration in obese non-diabetic patients
Resting, post-absorptive endogenous glucose production (EGP), fractional gluconeogenesis and liver glycogen concentration were assessed in 6 lean and 5 obese non-diabetic subjects undergoing elective abdomina...
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Article
Intracerebroventricular administration of neuropeptide Y to normal rats increases obese gene expression in white adipose tissue
The aim of this work was to determine the possible inter-relationship between neuropeptide Y (NPY, a hypothalamic stimulator of feeding) and adipose tissue expression of the ob protein (a novel potent inhibitor o...
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Article
Physiological concentrations of oxytocin powerfully stimulate insulin secretionin vitro
The effect of natural oxytocin on insulin secretion was investigated by using isolated, perfused rat pancreases. Oxytocin produced a dose-dependent stimulation of insulin secretion starting with a concentratio...
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Article
Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats
Intracerebroventricular neuropeptide Y (NPY) administration to normal rats for 7 days produced a sustained, threefold increase in food intake, resulting in a body weight gain of more than 40 g. Basal plasma in...
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Article
Involvement of non-esterified fatty acid oxidation in glucocorticoid-induced peripheral insulin resistance in vivo in rats
The mechanism by which glucocorticoids induce insulin resistance was studied in normal rats administered for 2 days with corticosterone then tested by euglycaemic hyperinsulinaemic clamps. Corticosterone admin...
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Article
Effect of a β-adrenergic agonist on glucose transport and insulin-responsive glucose transporters (GLUT4) in brown adipose tissue of control and obese fa/fa rats
A β-adrenergic agonist specific for brown adipose tissue, Ro 16-8714, was administered to control and obese insulin-resistant fa/fa rats and glucose utilisation measured in brown adipose tissue using the euglycae...
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Article
The contribution of hyperglycaemia and hypoinsulinaemia to the insulin resistance of streptozotocin-diabetic rats
The relative contribution of hyperglycaemia and hypoinsulinaemia was evaluated in rats made diabetic by streptozotocin administration. Four groups of rats were studied: untreated normal rats; streptozotocin-di...
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Article
Ocular complications in the old and glucose-intolerant genetically obese (fa/fa) rat
Genetically obese fatty (fa/fa) male rats with abnormal oral glucose tolerance associated with initial hyperinsulinaemia as well as control lean (FA/FA) rats were investigated for the development of retinal mi...
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Article
Dysregulation of glucose transport and transporters in perfused hearts of genetically obese (fa/fa) rats
The regulation of glucose transport in normal and insulin-resistant obese rat hearts have been studied by measuring glucose transport via the efflux of labelled 3-0-methyl-D-glucose. Glucose transporters in ob...
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Chapter and Conference Paper
Physiopathology and Possible Etiology of Hormonal Dysregulations and Insulin Resistance in Obese Rats: a Potential Model for Some Human Obesity
The genetically obese Zucker rat, characterized by the presence of the double recessive gene fa is a model of obesity and insulin resistance. It has a moderate hyperglycemia, and an abnormal oral glucose toleranc...
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Article
Abnormal regulation of pancreatic glucagon secretion in obese fa/fa rats
The results reported in the literature regarding glucagonaemia in genetically obese fa/fa rats are conflicting: normal, increased or decreased plasma glucagon levels have been reported. Due to the existence of se...
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Article
Heart glucose transport and transporters in rat heart: regulation by insulin, workload and glucose
Aspects of the regulation of the glucose transport by perfused hearts of normal rats have been studied by measuring glucose transport (via the efflux of labelled 3-O-methyl-D-glucose) and glucose transporters ...
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Article
Differential effect of steady-state hyperinsulinaemia and hyperglycaemia on hepatic glycogenolysis and glycolysis in rats
The action of glucose and of insulin on hepatic glucose production and metabolism has been studied in fed anaesthetized rats during hyperinsulinaemic clamp combined with various steady state levels of glycaemi...
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Article
The onset of liver glycogen synthesis in fasted-refed lean and genetically obese (fa/fa) rats
Lean and genetically obese (fa/fa) rats were fed ad libitum, or fasted for 17 h and then meal-fed for varying time intervals. During refeeding, glucose-6-phosphatase activity of lean rats declined to the low valu...
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Article
An hypothesis on the aetiology of obesity: dysfunction of the central nervous system as a primary cause
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Article
Oversecretion of glucagon by pancreases of ventromedial hypothalamic-lesioned rats: a re-evaluation of a controversial topic
Glucagon secretion by perfused pancreases of control and ventromedial hypothalamic-lesioned rats was studied in response to a mixture of 20 different amino-acids used at physiological or pharmacological concen...
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Article
Dysregulation of glucose transport in hearts of genetically obese (fa/fa) Rats
Overall D-glucose metabolism and 3-0-methylglucose transport were measured in the perfused heart preparation of lean and genetically obese (fa/fa) rats. Absolute values of basal and insulin-stimulated glucose met...
