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  1. No Access

    Chapter and Conference Paper

    Species Differences in DNA Damage by Butadiene: Role of Diepoxybutane

    In microsomal incubates 1,3-butadiene (BD) is metabolized by cytochrome P- 450 to its epoxide 1,2-epoxybutene (EB). Further metabolic transformation of the epoxide intermediate by epoxide hydrolase and/or mono...

    B. Jelitto, R. R. Vangala, R. J. Laib in Biological Monitoring of Exposure and the … (1989)

  2. No Access

    Chapter and Conference Paper

    Species Differences in Pharmacokinetics, Metabolism, and DNA Binding of Inhaled 1,3-Butadiene

    1,3-Butadiene, a major component in synthetic rubber and adiponitrile manufacture, has been found to produce cancer at multiple anatomic sites in two species of experimental animals. In an inhalation bioassay ...

    R. J. Laib, S. Deutschmann, B. Jelitto, R. R. Vangala… in Assessment of Inhalation Hazards (1989)

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    Chapter and Conference Paper

    Vinyl Acetate, a Structural Analog of Vinyl Carbamate, Fails to Induce Enzyme Altered Foci in Rat Liver

    Contradictory reports on a possible carcinogenicity of vinyl acetate (VAC) have caused concern about the metabolism and toxicity of this compound. Whereas the findings with VAC were negative in an inhalation b...

    R. J. Laib, H. M. Bolt in Toxic Interfaces of Neurones, Smoke and Genes (1986)

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    Chapter and Conference Paper

    Alkylation of RNA by Vinyl Chloride and Vinyl Bromide Metabolites in Vivo: Effect on Protein Biosynthesis

    Alkylation of DNA is viewed as representing the initial critical step in carcinogenesis induced by chemical substances. Vinyl chloride and vinyl bromide, compounds with proven carcinogenic potency toward the l...

    R. J. Laib, H. Ottenwälder, H. M. Bolt in Industrial and Environmental Xenobiotics (1981)

  5. No Access

    Chapter and Conference Paper

    Metabolic Activation and Pharmacokinetics in Hazard Assessment of Halogenated Ethylenes

    Halogenated ethylenes play an important role in occupational and environmental medicine. Several attempts at toxicological evaluation of such compounds have been recently published (Maltoni 1977; Lee et al. 19...

    H. M. Bolt, J. G. Filser, R. J. Laib in Industrial and Environmental Xenobiotics (1981)

  6. No Access

    Chapter and Conference Paper

    Induction of Pre-Malignant Hepatic Lesions: Comparative Effects of Vinyl Chloride and Trichloroethylene

    Formation of hemangioendotheliomas of liver in man and in experimental animals after exposure to vinyl chloride has focussed attention on possible cancerogenic effects of halogenated ethylenes. Vinyl chloride ...

    R. J. Laib, G. Stöckle, H. M. Bolt in Mechanism of Toxic Action on Some Target Organs (1979)