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  1. Carbene Complexes of Heme Proteins and Iron Porphyrin Models

    The possible formation of carbene complexes of cytochromes P450 enzymes in various metabolisms of xenobiotics is first described. In view of these...
    GĆ©rard Simonneaux, Paul Le Maux in Bioorganometallic Chemistry
    Chapter

  2. Ferroceneā€“Peptide Bioconjugates

    This chapter sketches an outline of ferroceneā€“peptide bioconjugates. A variety of ferroceneā€“peptide bioconjugates have been designed to induce...
    Toshiyuki Moriuchi, Toshikazu Hirao in Bioorganometallic Chemistry
    Chapter

  3. Catalytic Nickelā€“Ironā€“Sulfur Clusters: From Minerals to Enzymes

    The geochemical theory of the origin of life proposes that primordial, pre-biotic reactions were carried out in a metal-sulfide-rich environment...
    Anne Volbeda, Juan C. Fontecilla-Camps in Bioorganometallic Chemistry
    Chapter

  4. Microwave-Assisted Synthesis and Functionalization of 2-Pyridones, 2-Quinolones and Other Ring-Fused 2-Pyridones

    2-pyridones are important heterocycles with great applicability in medicinal chemistry and this core structure can be found in compounds with...
    Nils Pemberton, Erik Chorell, Fredrik Almqvist in Microwave-Assisted Synthesis of Heterocycles
    Chapter

  5. Total Synthesis of Marine Macrolides

    Recent progress (2002ā€“2005) of total syntheses of bioactive marine macrolides, lasonolide A, zampanolide, dactylolide, and leucascandrolide A, was...
    Mitsuru Shindo in Marine Natural Products
    Chapter

  6. Applications of Flexible Molecular Descriptors in the QSPRā€“QSAR Study of Heterocyclic Drugs

    Various formulations of optimal descriptors introduced by different authors during the last 10 years are discussed for the special case of...
    Pablo R. Duchowicz, Eduardo A. Castro, ... Emilio Benfenati in QSAR and Molecular Modeling Studies in Heterocyclic Drugs I
    Chapter

  7. QSAR and Molecular Modeling Studies of HIV Protease Inhibitors

    Acquired immunodeficiency syndrome (AIDS) and its related disorders, caused by retrovirus human immunodeficiency virus (HIV) are a major health...
    Rajni Garg, Barun Bhhatarai in QSAR and Molecular Modeling Studies in Heterocyclic Drugs I
    Chapter

  8. Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocycles

    This chapter aims to review recent developments in the synthesis of sulfur and nitrogen-containing heteroaromatic compounds under conditions that...
    Thierry Besson, ValƩrie ThiƩry in Microwave-Assisted Synthesis of Heterocycles
    Chapter

  9. Spectroscopic Study of the Structure of Zetekitoxin AB

    Zetekitoxin (former name: atelopidtoxin) was reported by Mosher and colleagues in 1969 as a potent, water-soluble, guanidinium toxin found in...
    Mari Yotsu-Yamashita in Marine Natural Products
    Chapter

  10. The Chemistry of 2-(1H)-Pyrazinones in Solution and on Solid Support

    An overview on the microwave-enhanced synthesis and decoration of the 2(1H)-pyrazinone system is presented. Scaffold decoration using...
    Nadya Kaval, Prasad Appukkuttan, Erik VanĀ der Eycken in Microwave-Assisted Synthesis of Heterocycles
    Chapter

  11. In silico Studies on PPARĪ³ Agonistic Heterocyclic Systems

    Several heterocyclic derivatives like oxazolidinediones, thiazolidinediones, tetarazoles, phenoxazines, etc. are being developed for the treatment...
    Smriti Khanna, Raman Bahal, Prasad V. Bharatam in QSAR and Molecular Modeling Studies in Heterocyclic Drugs I
    Chapter

  12. Manganese(III)-Based Peroxidation of Alkenes to Heterocycles

    Synthesis of endoperoxides and hydroperoxides using tris(2,4-pentanedionato)manganese(III) or manganese(III) acetate is described. The reaction of...
    Hiroshi Nishino in Bioactive Heterocycles I
    Chapter

  13. n-Body Decomposition Approach to the Calculation of Interaction Energies of Water Clusters

    A new methodology is proposed in which large basis set MP2-level calculations can be extended to water clusters with as many as 50 monomers. The...
    R. A. Christie, K. D. Jordan in Intermolecular Forces and Clusters II
    Chapter

  14. Intermolecular Interactions via Perturbation Theory: From Diatoms to Biomolecules

    This article is devoted to the most recent, i.e. taking place within the last few years, theoretical developments in the field of intermolecular...
    Krzysztof Szalewicz, Konrad Patkowski, Bogumil Jeziorski in Intermolecular Forces and Clusters II
    Chapter

  15. Enzymatic Polymerization to Polysaccharides

    Polysaccharides are formed by repeated glycosylations between a sugar donor and a sugar acceptor. This chapter reviews the in vitro synthesis of...
    Shiro Kobayashi, Masashi Ohmae in Enzyme-Catalyzed Synthesis of Polymers
    Chapter

  16. PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates

    The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only...
    Gianfranco Pasut, Francesco M. Veronese in Polymer Therapeutics I
    Chapter

  17. Polymer Therapeutics for Cancer: Current Status and Future Challenges

    Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...
    Ronit Satchi-Fainaro, Ruth Duncan, Carmen M. Barnes in Polymer Therapeutics II
    Chapter

  18. Computer-Aided Conformation-Dependent Design of Copolymer Sequences

    A survey is given of the simulation methods as applied to the design of nontrivial sequences in synthetic copolymers aimed at achieving desired...
    Pavel G. Khalatur, Alexei R. Khokhlov in Conformation-Dependent Design of Sequences in Copolymers I
    Chapter

  19. After-Action of the Ideas of I.M. Lifshitz in Polymer and Biopolymer Physics

    We review the development of ideas in polymer physics initially formulated by I.M. Lifshitz. We start with general issues in polymer statistics,...
    Alexander Yu. Grosberg, Alexei R. Khokhlov in Conformation-Dependent Design of Sequences in Copolymers II
    Chapter

  20. Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization

    This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize...
    Timothy J. Deming in Peptide Hybrid Polymers
    Chapter
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