38 Result(s)
within
Chapter
Teruo Okano
English
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Chapter
Design of Temperature-Responsive Cell Culture Surfaces for Cell Sheet-Based Regenerative Therapy and 3D Tissue Fabrication
This chapter describes the concept of “cell sheet engineering” for the creation of transplantable cellular tissues and organs. In contrast to scaffold-based tissue engineering, cell sheet engineering facilitat...
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Chapter
Cell Sheet Tissue Engineering for Heart Failure
In recent years, regenerative medicine using cells for treating tissue defects has been in the spotlight as a new treatment for severe heart failure. Direct injection of bone marrow-derived cells and isolated ...
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Chapter
Stimuli-Responsive Hydrogels and Their Application to Functional Materials
Many kinds of stimuli-responsive polymer gels that respond to the change in their surroundings such as solvent composition, temperature, pH, and supply of electric field have been developed. They are of intere...
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Chapter and Conference Paper
Fabrication of Three-Dimensional Tissues with Perfused Microchannels
Recently, researchers have challenged to create three-dimensional (3-D) tissues with tissue engineering technology in order to establish in vitro models and new therapy for damaged organ. We have developed cel...
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Chapter
On-Off Switching Properties of ultra thin Intelligent Temperature-Responsive Polymer Modified Surface
Intelligent temperature-responsive polymers are currently utilized in a variety of fields within engineering and medicine. Particularly, special attention has been paid to the temperature-responsive polymer, p...
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Chapter and Conference Paper
Retinal Pigment Epithelial Cells from Thermally Responsive Polymer-Grafted Surface Reduce Apoptosis
Brain-derived neurotrophic factor (BDNF) has reported to show photoreceptor protection for retinal degeneration either genetically programmed,1 or light induced experimental retinal degeneration.2 Genetically mod...
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Chapter
Cell Sheet Technology for Myocardial Tissue Engineering
Myocardial tissue regeneration including isolated cell transplantation and recruitment of bone marrow stem cells via cytokines have now emerged as one of the most promising treatments for patients suffering fr...
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Chapter
Clinical Survey of Cell Therapy in Japan
Background: Therapeutic angiogenesis by using cells is being performed in Japan. However, it is unknown in how many centers and how these therapies are performed. The efficacy and side effects are also unknown...
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Chapter
Challenges in Polymer Therapeutics
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Chapter and Conference Paper
Highly Blood-Compatible Surface Consisting of a Silicon-Containing Block Copolymer with Supramolecular Structure
With the aim of develo** a high-performance membrane-type artificial lung, a novel silicon-containing hydrophilic-hydrophobic block copolymer was prepared using a living anionic polymerization technique. To ...
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Chapter and Conference Paper
Temperature-Sensitive Changes in Surface Properties of a Poly(N-Isopropylacrylamide) Hydrogel Layer
A poly(N-isopropylacrylamide)-coated glass was prepared and its interfacial electrokinetic properties were studied with a special emphasis on the phase transition behavior of the hydrogel. The electro-osmotic ...
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Chapter and Conference Paper
Pharmaceutical Aspects of Block Copolymer Micelles
We studied the stability of micelles of poly(ethylene oxide-block-ß benzyl L aspartate) (PEO-PBLA) containing doxorubicin (DOX), an anti-cancer drug. DOX entrapped in PEO-PBLA micelles had greater chemical stabil...
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Chapter and Conference Paper
Application of Hema-St Block Copolymer Coated Small Caliber Vascular Graft for Veins
We were already reported that the amphiphilic block copolymer composed from 2-hydroxyethylmathacryrate and styrene(HSB) which formed micro-domain structure show excellent nonthombogenicity. In this study, we a...
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Chapter and Conference Paper
Micelle Forming Polymeric Anticancer Drug Containing Chemically Bound and Physically Incorporated Adriamycin
Micelle forming polymeric drug(MFPD) containing chemically bound and physically incorporated adriamycin(ADR) was designed. Three MFPD samples containing various contents of physically incorporated ADR were pre...
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Chapter and Conference Paper
Temperature-Modulated Surface Hydrophilic/Hydrophobic Alterations for Novel Recovery of Cultured Cells
Poly(N-sopropylacrylamide) (PIPAAm)-grafted surfaces show hydrophilic/hydrophobic surface property alteration upon temperature changes. Utilizing this property changes, we can cultivate cells on its surface at 37...
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Chapter and Conference Paper
The Pulsatile Release System of Macromolecular Drugs from Alginate Gel Beads
We investigate the possible applicability of alginate gel beads for controlled release system of water-soluble macromolecular drugs, using Fluorescein Isothiocyanate Dextran (FITC-dex) as the model compound. L...
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Chapter and Conference Paper
Induction of Endothelial Cell Differentiation on Copolymer Surfaces Having Phenylboronic Acid Groups
The ternary copolymers composed of m-acrylamidophenylboronic acid, N,N-dimethylaminopropylmethacrylamide and N-isopropylacrylamide were synthesized. Bovine aortic endothelial cells (BAECs) on the copolymer substr...
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Chapter and Conference Paper
Intelligent Materials
Poly(N-isopropylacrylamide) (PIPAAm) is well-known to change its structure in response to temperature in aqueous solutions [1,2]. Polymer chains of IPAAm hydrate to form expanded structures in water at lower solu...
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Chapter and Conference Paper
Amine Effect on Controlled Release of Insulin from Phenylboronic Acid Gel in Physiological pH
An insulin delivery system comprising phenylboronic acid (PBA) hydrogel was investigated for efficacy at physiological pH by an addition of amino moiety. Release of gluconated insulin from hydrogel beads havin...
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Chapter and Conference Paper
Molecular Architecture of Temperature-Responsive Bioconjugates
Chemical modification of biomolecules with synthetic and natural polymers has developed new applications of proteins in the fields of medicine, bio-engineering and bioreactor. We have been investigating polyme...
