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Chapter
Making Methionine: A Love Affair with Folate
I am deeply honored to be chosen as the Frederick Gowland Hopkins lecturer by my friends and colleagues. The honor is particularly special for me because my father traveled from New York to Cambridge to do his...
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Chapter
Methylenetetrahydrofolate Reductase: Comparison of the Enzyme from Mammalian and Bacterial Sources
Methylenetetrahydrofolate reductase catalyzes the reduction of methylenetetrahydrofolate to methyl-tetrahydrofolate, which serves as the methyl donor for the conversion of homocysteine to methionine in the rea...
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Chapter
Cobalamin-Dependent and Cobalamin-Independent Methionine Synthases in Escherichia coli: Two Solutions to the Same Chemical Problem
Two genes encoding proteins with methionine synthase activity are found in Escherichia coli. Both enzymes use methyltetrahydrofolate as a methyl donor to catalyze the conversion of homocysteine to methionine, as ...
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Chapter
The Role of Folylpolyglutamates in the Regulation of Folate Metabolism
Folylpolyglutamates have been shown to function as potent inhibitors, relative to the corresponding monoglutamates, of two enzymes involves in the metabolism of methylenetetrahydrofolate (CH2-H4folate) in mammali...
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Chapter
Interactions of adenosylmethionine with methylenetetrahydrofolate reductase
Commercial preparations of AdoMet are isolated from yeast, and the AdoMet has the configuration of the natural diastereoisomer at both the sulfonium pole and the methionyl substituent. However, such preparatio...
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Chapter
A New Intermediate in TPNH-Linked Flavoproteins
The early studies of Michaelis et. al. (1) clearly indicated that partial reduction of the flavin coenzymes led to the production of colored radical intermediates. Except for the catio-nic radical, which is produ...