30 Result(s)
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Chapter
Inflammatory Components of the Thyroid Cancer Microenvironment: An Avenue for Identification of Novel Biomarkers
The incidence of thyroid cancer in the United States is on the rise with an appreciably high disease recurrence rate of 20–30%. Anaplastic thyroid cancer (ATC), although rare in occurrence, is an aggressive fo...
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Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity
Thyroid cancer incidence is increasing at an alarming rate, almost tripling every decade. About 44,280 new cases of thyroid cancer (12,150 in men and 32,130 in women) are estimated to be diagnosed in 2021, wit...
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Chapter
Discovery of Cell-Surface Vimentin (CSV) as a Sarcoma Target and Development of CSV-Targeted IL12 Immune Therapy
This chapter discusses a novel target of osteosarcoma (OS), cell-surface vimentin (CSV), and a novel generation of interleukin-12 (IL12), CSV-targeted IL12, for treating OS tumor metastasis. Vimentin is a know...
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Adipose Tissue-Resident Regulatory T Cells
Tissue-resident immune cells play critical roles in regulating tissue function and homeostasis. Obesity-associated visceral adipose tissue inflammation is attributed to the accumulation of M1 macrophages which...
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Regulation of Metabolism Across Different Subsets of T Cells in Cancer
T cells play a critical role to defend against tumor and maintain immune homeostasis. The diverse functions of T cells require precise regulation of metabolic pathways. Recent studies reveal that metabolic cha...
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Chapter
Macrophages and RhoA Pathway in Transplanted Organs
RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also p...
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Chapter
Human Papillomavirus-Related Cancers
Human papillomavirus (HPV) infection is associated with several cancers such as cancer in the cervix, vagina, and vulva and oropharyngeal, anal, penile, and cutaneous carcinomas, which is regarded as a great p...
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Transcriptional Regulation of T Cell Metabolism Reprograming
T cell activation, differentiation, and function are tightly regulated by a complex network of transcription factors, epigenetic modifications, and signaling pathways of both TCR and cytokines. Over the past d...
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Chapter
Immune Cell Metabolism in Tumor Microenvironment
Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrate...
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Chapter
Prion Protein Family Contributes to Tumorigenesis via Multiple Pathways
A wealth of evidence suggests that proteins from prion protein (PrP) family contribute to tumorigenesis in many types of cancers, including pancreatic ductal adenocarcinoma (PDAC), breast cancer, glioblastoma,...
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Chapter
Kaposi’s Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology
Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-assoc...
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Discoidin Domain Receptor 2 in Development of Osteoarthritis
Osteoarthritis is a progressive disease of synovial joints. The ultimate consequence of the disease is the breakdown of cartilage and bone, resulting in joint pain, stiffness, and functional disability. Curren...
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Mutational Profile of HPV-Positive HNSCC
This chapter summarizes the mutational profile of head and neck squamous cell cancer (HNSCC) associated with infection of the human papillomavirus (HPV). Focusing on next-generation sequencing studies, the dif...
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Chapter
The Role of miRNAs in the Development of Normal Pancreas and Pancreatic Cancer, and Their Roles in Tumor Progression
The microRNAs (miRNAs) have been shown to play important roles in the control of many normal biological processes including cell differentiation and organogenesis. During the development of normal pancreas, se...
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The RCAS/TVA Somatic Gene Transfer Method in Modeling Human Cancer
Most human solid cancers arise from one or a few mutated cells in an otherwise normally developed tissue. In order to understand the genetic and cellular basis of these tumors, it is necessary to have models t...
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Chapter
Exogenous Hormones
Women worldwide have been prescribed medications containing female steroid sex hormones for the past several decades. These medications primarily containing various derivatives of estrogen and/or progesterone ...
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Chapter
Environmental and Occupational Exposures
Breast cancer incidence rates have increased substantially over the past several decades in most Westernized countries, with great variation in incidence rates between countries (Kamangar et al. 2006). Given s...
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Chapter
Breast Cancer Biology and Clinical Characteristics
While breast cancer is often studied as a single disease, advances in our understanding of the epidemiology, biology, and molecular basis for breast cancer indicate that it is a heterogeneous disease that can ...
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Chapter
Endogenous Hormones
Given the consistent associations between various reproductive and hormonally related factors and breast cancer risk, sex hormones have long been implicated as key players in breast cancer etiology. However, e...
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Chapter
Variable selection in regression - estimation, prediction,sparsity, inference
