8 Result(s)
within
Chapter
Qi** Li
Biomedicine
Cancer Research
Immunology
Medical Microbiology
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Chapter
Adipose Tissue-Resident Regulatory T Cells
Tissue-resident immune cells play critical roles in regulating tissue function and homeostasis. Obesity-associated visceral adipose tissue inflammation is attributed to the accumulation of M1 macrophages which...
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Regulation of Metabolism Across Different Subsets of T Cells in Cancer
T cells play a critical role to defend against tumor and maintain immune homeostasis. The diverse functions of T cells require precise regulation of metabolic pathways. Recent studies reveal that metabolic cha...
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Chapter
Macrophages and RhoA Pathway in Transplanted Organs
RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also p...
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Chapter
Transcriptional Regulation of T Cell Metabolism Reprograming
T cell activation, differentiation, and function are tightly regulated by a complex network of transcription factors, epigenetic modifications, and signaling pathways of both TCR and cytokines. Over the past d...
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Chapter
Immune Cell Metabolism in Tumor Microenvironment
Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrate...
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Chapter
Mutational Profile of HPV-Positive HNSCC
This chapter summarizes the mutational profile of head and neck squamous cell cancer (HNSCC) associated with infection of the human papillomavirus (HPV). Focusing on next-generation sequencing studies, the dif...
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Chapter
Chromatin Remodeling and Androgen Receptor-Mediated Transcription
It has become apparent that the expression of human genes in chromatin is regulated by post-translational structural changes in histones, which form the major protein component of nucleosomes in chromatin. The...
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Chapter
Images of Cleavage: Tumor Proteases in Action
The roles of proteases in cancer are now known to be much broader than simply degradation of extracellular matrices during tumor invasion and metastasis. Furthermore, proteases from tumor-associated cells (e.g...
