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  1. No Access

    Chapter

    Yeast Based Sensors

    Since the first microbial cell sensor was studied by Karube et al. in 1977, many types of yeast based sensors have been developed as analytical tools. Yeasts are known as facultative anaerobes. Facultative ana...

    Mifumi Shimomura-Shimizu, Isao Karube in Whole Cell Sensing Systems I (2010)

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    Chapter

    Applications of Microbial Cell Sensors

    Since the first microbial cell sensor was studied by Karube et al. in 1977, many types of microbial cell sensors have been developed as analytical tools. The microbial cell sensor utilizes microbes as a sensin...

    Mifumi Shimomura-Shimizu, Isao Karube in Whole Cell Sensing System II (2010)

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    Chapter

    Development of Microbial Sensors and Their Application

    Many types of microbial sensors have been developed as analytical tools since the first microbial sensor was studied by Karube et al. in 1977. The microbial sensor consists of a transducer and microbe ...

    Hideaki Nakamura, Mifumi Shimomura-Shimizu, Isao Karube in Biosensing for the 21st Century (2008)

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    Chapter and Conference Paper

    Chemical Vapor Sensor Using a Lipid-Coated SAW Resonator Oscillator

    The sensitivity of piezoelectric Detectors and surface acoustic wave (SAW) devices is directly proportional to the square of the resonant frequency, and is inversely proportional to the surface area. Therefore...

    Eiichi Tamiya, Isao Karube in Olfaction and Taste XI (1994)

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    Chapter and Conference Paper

    Development of Micro—Biosensors for Brain Research

    Neurotransmitters play important roles in the brain since they are the key link in communication between neurons. Acetylcholine is the transmitter of motor neurons in the spinal cord as well as in all the nerv...

    Eiichi Tamiya, Isao Karube in Bioproducts and Bioprocesses 2 (1993)

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    Chapter

    Microbial Sensors and Microbiosensors

    A novel BOD sensor with a new principle employing a luminous bacterium, Photobacterium phosphoreum, was developed. The increased intensity of luminescence resulting from the cellular assimilation of organic compo...

    Isao Karube, Kenji Yokoyama in Uses of Immobilized Biological Compounds (1993)

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    Chapter

    Micro-biosensors for Clinical and Food Analyses

    Micro-biosensors for glucose and fish freshness were constructed by using silicon fabrication technology. A micro-H2O2 electrode was used to make a micro-glucose sensor. Glucose oxidase was immobilized on an orga...

    Eiichi Tamiya, Isao Karube in Transactions of the Materials Research Society of Japan (1990)

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    Chapter

    Microbiosensors and Immunosensors

    Chemical reactions in organisms proceed smoothly because of the action of catalysts such as enzymes. These are highly specific for chemical substances with which they form complexes to promote their reactions....

    Isao Karube, Atsushi Seki, Koji Sode in Microbial Enzymes and Biotechnology (1990)

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    Chapter and Conference Paper

    Microbiosensors for Clinical and Process Analysis

    Microbiosensors for urea and adenosine triphosphate (ATP) are prepared with ion sensitive field effect transistor (ISFET) modified by enzymes such as urease and H +-ATPase respectively. The Micro-urea sensor give...

    Isao Karube, Eiichi Tamiya in Bioproducts and Bioprocesses (1989)

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    Chapter

    Immunosensors

    The development of practical immunosensors is an important topic for biosensor research. Recently the authors have demonstrated novel immunosensors, such as the immuno-FET sensor, the piezoimmunosensor, the pu...

    Isao Karube, Masao Gotoh in Analytical Uses of Immobilized Biological … (1988)

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    Chapter

    Micro-Biosensor

    ISFET is utilized as a pH sensitive transducer, so that the enzyme or micro-organisms, which catalyze the reaction that involves pH changes, were coupled with the ISFET to construct a micro-biosensor. A micro-...

    Isao Karube, Izumi Kubo in Analytical Uses of Immobilized Biological … (1988)

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    Chapter

    Enzyme and Microbial Sensor

    Various enzyme and microbial sensors based on amperometric determination were developed. These sensors were composed of enzyme(s) or/and microorganisms immobilized in membranes on an oxygen electrode. Hypoxant...

    Isao Karube, Koji Sode in Analytical Uses of Immobilized Biological … (1988)

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    Chapter

    Electric Pulse Accelerated Immunoassay

    Variqus antigens including proteins, peptides, drugs and microorganisms are determined by immunoassay. The immunoassay is based on the specific binding reaction of an antigen to its antibody. Immunoreaction re...

    Isao Karube, Eiichi Tamiya in Electrochemical Sensors in Immunological Analysis (1987)

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    Chapter

    Application of Photosensitive Immobilized α-Chymotrypsin to Synthetic Reaction

    Hydrolytic enzymes can be used to catalyze the synthesis of the compounds that they normally hydrolyze. Substances which undergo reversible color formation under light irradiation are called photochromic compo...

    Isao Karube, Shuichi Suzuki in Enzyme Engineering (1980)

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    Chapter

    Microbial Sensors for Ethyl Alcohol, Acetic Acid and Ammonia

    Microbial sensors consisting of immobilized whole cells and electrochemical devices have been developed for the determination of raw materials, cell population and products in microbial media (1,2,3). Microbia...

    Isao Karube, Shuichi Suzuki in Enzyme Engineering (1980)

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    Chapter

    Electrochemical Determination of Lipids in Serum

    The determination of lipids in serum is very important in clinical analysis. Quantitative determination of lipids can be carried out colorimetrically; however, pretreatment such as lipid extraction and separat...

    Suichi Suzuki, Isao Karube in Enzyme Engineering (1980)

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    Chapter

    Biochemical Energy Conversion System

    Considerable world-wide interest has arisen in development of new energy conversion systems. Utilization of biomass and waste water is attractive for energy production. The authors succeeded in stabilization o...

    Shuichi Suzuki, Isao Karube, Tadashi Matsunaga, Hiromichi Kayano in Enzyme Engineering (1980)

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    Chapter

    Electrochemical Preparation of Enzyme-Collagen Membrane and Its Application

    The electrochemical preparation of membrane from fibrous protein such as collagen has been developed in our laboratory since 1966 (1,2,3).

    Shuichi Suzuki, Masuo Aizawa, Isao Karube in Immobilized Enzyme Technology (1975)