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Chapter
PCA Modelling of Multi-species Cell Clusters: Ganglion Development in the Gastrointestinal Nervous System
A defining characteristic of the enteric nervous system (ENS) is mesoscale patterned entities called ganglia. Ganglia are clusters of neurons with associated enteric neural crest (ENC) cells, which form in the...
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Chapter and Conference Paper
Modeling Development and Disease in Our “Second” Brain
The enteric nervous system (ENS) in our gastrointestinal tract, nicknamed the “second brain”, is responsible for normal gut function and peristaltic contraction. Embryonic development of the ENS involves the c...
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Chapter
Neural Crest and the Development of the Enteric Nervous System
The formation of the enteric nervous system (ENS) is a particularly interesting example of the migratory ability of the neural crest and of the complexity of structures to which neural crest cells contribute. ...
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Chapter
The Neural Crest
The concept of the epithelial-mesenchymal transition (EMT) arose from developmental biology, (see ref. 1) where EMT occurs in many situations, each being predictable, stereotyped and with the outcomes often dr...
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Chapter
Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition
The epithelial to mesenchymal transition (EMT) is characterized by the loss of epithelial characteristics and the gain of mesenchymal attributes in epithelial cells. It has been associated with physiological a...