28 Result(s)
within
Chapter
Axel Haverich
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Chapter and Conference Paper
Early graft failure after heart transplantation: Circulatory assist versus retransplantation
Early graft failure requiring mechanical circulatory support occurred in 12 of our first 257 patients following cardiac transplantation. Three patients had biventricular myocardial failure and were supported b...
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Chapter
Cell-cell and cell-matrix adhesion molecules in human heart and lung transplants
The interaction of immune cells with endothelial and target cells and extracellular matrix in human organ transplants is regulated by a number of receptor-ligand molecules. The molecules mediating intercellula...
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Principles of heart allocation
Cardiac transplantation has emerged as an accepted mode of therapy for end stage heart failure. Patients whose life expectancy would otherwise be measured in weeks or months can be offered a form of surgical i...
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Engineering of a miniature 3-D hepatic cell plate culture model
The development of primary liver cell culture techniques has a long standing history that has contributed significantly to our current knowledge about the relevance of individual aspects of the hepatic microen...
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Enrichment of Cardiac Pacemaker-Like Cells: Neure gulin-1 and Cyclic amp Increase If-Current Density and Connexin 40 mRNA Levels in Fetal Cardiomyocytes
Generation of a large number of cells belonging to the cardiac pacemaker system would constitute an important step towards their utilization as a biological cardiac pacemaker system. The aim of the present stu...
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Lung Perfusion in Clinical Heart-Lung Transplantation
The initial steps of cardiac transplantation were conducted more than 100 years ago by Carerel and Guthrie in 1905, employing an acute model with anastomosis of the neck vessels to cardiac structures.1 Reports of...
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Pathology and Classification of Mitral Valve Disease
Normal mitral valve function needs structural integrity and coordinated interaction among its structures including leaflets, annulus, chordae tendinae, papillary muscles, left atrium, and the left ventricle. M...
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Heart and Cardiovascular Engineering
End stage organ diseases of the cardiovascular system are associated with intense individual harm, tremendous problems in medical therapy, and last but not least high socio-economic debits. The concept of “Tis...
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Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts: A Finite Element Investigation
Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechan...
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Techniques for Driveline Positioning
Next to the improvements in implantation procedure of the pump itself [1], there are some other parts of the LVAD system, which are crucial in the process of LVAD therapy such as graft anastomosis, controller ...
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Which Approach? Traditional Versus MICS
Consistently enhanced technology, research, and gain of clinical experience within the first decade of this century have established ventricular assist devices (VADs) as important option for the treatment of c...
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Left Ventricular Assist Devices – A State of the Art Review
Cardiovascular diseases are the leading cause of mortality rates throughout the world. Next to an insufficient number of healthy donors, this has led to increasing numbers of patients on heart transplant waiti...
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Introduction
is the progressive buildup of plaque inside arteries and the leading cause of vascular disease worldwide. Despite decades of research, the pathomechanisms of disease development are still not known. Contrar...
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The Effect of Growth and Aging on the Vascular Architecture
is a disease of medium-sized and large arteries, and as such, we will first delve into the architecture of the arterial vessel wall. We will discuss how growth necessitates changes to the structure of arter...
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Risk Factors and Prevention in Light of Atherosclerosis Being a Microvascular Disease
Accumulating evidence demonstrates that dysfunctional contributes to localized that precipitates site-specific plaque formation. Given the importance of the blood vessel wall microvasculature in disease ...
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Supporting Microvasculature Function
Changing the mind-set of clinicians and researchers in the field of to reconsider the importance of the arterial wall is crucial for understanding fundamental aspects of disease progression and for identif...
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Atherosclerosis Risk Factors
is defined as a variable that is causally associated with an increased rate of the disease and is an independent, significant predictor of the risk of develo** the disease. Risk factors of range from un...
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Incriminating Evidence for the Role of the Microvasculature in Atherosclerosis
Different vascular beds show a different susceptibility to and, even within diseased vessels themselves, plaques display a distinct localization. and blood vessel wall are distinctly distributed in the a...
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New Ways to Target Vasa Vasorum for the Prevention and Treatment of Atherosclerosis
Given that and their dysfunction are involved in the initiation and progression of , several new therapeutic opportunities can be envisioned. In particular, prevention or treatment of microthrombus formatio...
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Lungen- und Herz-Lungen-Transplantation
Die Lungentransplantation ist eine etablierte Therapie bei Patientinnen und Patienten mit terminalen Lungenerkrankungen, die zu einer Verbesserung der Lebensqualität und – in Abhängigkeit von der Grunderkranku...
