2,428 Result(s)
within
English
Biochemistry, general
Pharmacology/Toxicology
Yi** **
Chapter
Conference Paper
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Chapter and Conference Paper
Combined Influence of Insulin and Glucagon Upon Hepatocytes in Rats with Liver Loss or Viral Injury
Insulin and glucagon act in synergy to promote hepatic regeneration in eviscerated rats and to enhance survival in mice with viral hepatitis. Relatively low doses of insulin and high doses of glucagon are requ...
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Chapter and Conference Paper
The Role of Glucagon in Amino Acid Homeotasis
The uptake of amino acids by the liver, the plasma level of glucagon and the insulin to glucagon ratio have an important role in the amino acid homeostasis of man. Evidence that glucagon may be more important ...
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Chapter and Conference Paper
Modes of action of antimicrobial agents
This article has traced the development of a strategy for mode of action studies of chemotherapeutic drugs from its blindfolded empirical beginnings to the current state in which it is possible to assign a cat...
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Chapter and Conference Paper
Tilorone hydrochloride: The drug profile
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Chapter and Conference Paper
Regulation of Hepatic Gluconeogenesis by Glucagon in the Rat
Glucagon (2 × 10−9 M) increased the rates of gluconeogenesis, ureogenesis and ketogenesis by the perfused isolated rat liver. Glucagon to insulin ratios of 2.6 reversed all the metabolic effects induced by the ad...
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Chapter and Conference Paper
Lowering of Plasma Lipids, The Major Effect of Repeated Glucagon Administration in Rats
The most prominent long lasting effect of repeated injection of commercial pancreatic glucagon (0.1–30 mg/kg s.c. twice daily) in fed and starving rats is a depression of the major plasma lipids. This lipid-lo...
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Chapter and Conference Paper
Morphologic Study of Glucagon Release
The authors studied the release of glucagon from isolated pancreatic islets using thin section preparations, freeze-fracture techniques and radioimmunoassay. The evidence strongly suggests that exocytosis is a...
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Chapter and Conference Paper
Syntheses and activity of heteroprostanoids
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Chapter and Conference Paper
Metabolic Fuels in the Embryo and the Newborn
Although insulin and glucagon can be detected on the 11th day of gestation in the rat fetal pancreas, the secretion and biologic action of these hormones do not reach maturity until after the 30th day of postn...
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Chapter and Conference Paper
High Molecular Weight Glucagons from Avian Islets and Fetal Bovine Pancreas
Extracts of pigeon pancreatic islets and fetal bovine pancreas contain a 9000 dalton and a 69,000 dalton molecule with glucagon-like immunoreactivity. The avian 9000 dalton molecule, purified by gel filtration...
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Chapter and Conference Paper
Glucose Homeostasis in the Newborn
Measurements of insulin and glucagon secretion by pancreatic islets isolated from rat pups at various times after birth (0 hours to 15 days) indicate a progressive decline in basal insulin release and a progre...
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Chapter and Conference Paper
The Effects of Exogenously Induced Hyperglucagonemia in Insulin-Treated Diabetics
A recent report that the continuous intravenous infusion of glucagon failed to worsen hyperglycemia in two insulin-treated juvenile diabetics has raised doubts as to the importance of hyperglucagonemia in insu...
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Chapter and Conference Paper
Quantification of Plasma Glucagon Immunoreactive Components in Normal and Hyperglucagonemic States
Chromatography of human and dog plasma on Bio Gel P-30 columns revealed the presence of as many as four glucagon fractions reacting with a “pancreatic glucagon-specific” antiserum (30K). These fractions have a...
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Chapter and Conference Paper
The Issues Related to Abnormal A Cell Function in Diabetes Mellitus
This paper discusses the issues related to abnormal A-cell function in diabetes mellitus, under the following headings: 1) Problems of radioimmunoassay of glucagon; 2) The measurement of plasma levels of gluca...
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Chapter and Conference Paper
The Nature of Hyperglucagonemia in Diabetes Mellitus
The nature of hyperglucagonemia in diabetes mellitus was investigated in diabetic patients and in experimental animals. The following characteristics of diabetic hyperglucagonemia were demonstrated: decreased ...
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Chapter and Conference Paper
Plasma Immunoreactive Glucagon in Depancreatized Animals
The basal level of immunoreactive A cell glucagon (GI, as measured with a pancreatic glucagon specific antiserum) and of gut glucagon-like immunoreactive material (gut GLI: calculated as the difference between...
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Chapter and Conference Paper
Glucagon-Like Materials in Porcine and Rat Intestinal Mucosa
Extracts of gastrointestinal tissue contain glucagon-like immunoreactive (GLI) materials with molecular weights varying between 2000 and 30,000. Some of them react with antisera specific for the C-terminal, ot...
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Chapter and Conference Paper
Glucagon Metabolism in Potential Diabetes Mellitus. Studies of Discordant Twins and Patients After Myocardial Infarction
Plasma glucagon responses to glucose have been restudied in 12 unaffected twins of diabetics after an interval of 5 years and contrasted with 12 normal (N) and 12 diabetic subjects (D). Once more their glucago...
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Chapter and Conference Paper
Role of the Submaxillary Gland and of the Kidney in the Hyperglucagonemia of Eviscerated Rats
Significant quantities of A cell and total glucagon were found in the systemic blood of eviscerated rats, especially following arginine infusion. These findings and the hyperglucagonemia previously observed in...
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Chapter and Conference Paper
Effect of Long Term Sulfonylurea Therapy on Glucagon Levels in Maturity Onset Diabetes Mellitus
Glucagon secretion was studied before and after the control of hyperglycemia in 15 maturity onset male diabetics (mean age 56.1 yrs; mean duration of diabetes 7.3 yrs). Optimum control of hyperglycemia was ach...
