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Article
Open AccessAllosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification of PPM1D are found across numerous cancer types. GSK...
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Article
Open AccessPublisher Correction: A Fast and Refined Cancer Regions Segmentation Framework in Whole-slide Breast Pathological Images
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessG-protein signaling is required for increasing germline stem cell division frequency in response to mating in Drosophila males
Adult stem cells divide to renew the stem cell pool and replenish specialized cells that are lost due to death or usage. However, little is known about the mechanisms regulating how stem cells adjust to a dema...
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Article
Open AccessA Fast and Refined Cancer Regions Segmentation Framework in Whole-slide Breast Pathological Images
Supervised learning methods are commonly applied in medical image analysis. However, the success of these approaches is highly dependent on the availability of large manually detailed annotated dataset. Thus a...
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Article
Open AccessHaze smoke impacts survival and development of butterflies
The Southeast Asian transboundary haze contains a mixture of gases and particles from forest fires and negatively impacts people’s health and local economies. However, the effect of the haze on organisms other...
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Article
Open AccessEnhanced Defluoridation Using Novel Millisphere Nanocomposite of La-Doped Li-Al Layered Double Hydroxides Supported by Polymeric Anion Exchanger
A novel nanocomposite bead LaLiAl-LDH@201 was fabricated by do** a small amount of La into nanocrystalline Li/Al layered double hydroxides (LDHs) pre-confined inside polystyrene anion exchanger D201 (LiAl-LD...
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Article
Open AccessAssociation of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients
Elevated plasma homocysteine (Hcy) is suggested as an independent risk factor for stroke. We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial ...
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Article
Open AccessAssociation of Inter-arm Blood Pressure Difference with Asymptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients
Inter-arm blood pressure (BP) difference has been associated with ischemic stroke. Local atherosclerosis of stroke differ among vulnerable individuals, whereas intracranial arterial stenosis (ICAS) is more fre...