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Article
Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain
RNA interference (RNAi) for spinocerebellar ataxia type 1 can prevent and reverse behavioral deficits and neuropathological readouts in mouse models, with safety and benefit lasting over many months. The RNAi ...
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Article
Prediction of intravenous immunoglobulin resistance in Kawasaki disease in children
We aimed to explore predictive measures for intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD).
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Article
Epigenetic Downregulation of Scn3a Expression by Valproate: a Possible Role in Its Anticonvulsant Activity
Upregulation of sodium channel SCN3A expression in epileptic tissues is known to contribute to enhancing neuronal excitability and the development of epilepsy. Therefore, certain strategies to reduce SCN3A expres...
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Article
Synthesis and Fluorescent Properties of a Chiral 2D Tetranuclear Cd(II) Coordination Polymer Based on Asymmetrical Biphenyltetracarboxylate
Solvothermal reaction of Cd(OAc)2·2H2O and biphenyl-2,3,3′,5′-tetracarboxylic acid (H4bptca) in DMF/H2O afforded one novel coordination polymer [Cd4(bptca)2(DMF)4]n (1). X-ray structural analysis reveals that com...
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Article
Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy
The brain vasculature forms an immense network such that most neural cells are in contact with a microvessel. Here we tested the hypothesis that endothelia lining these vessels can be harnessed to create a cel...
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Article
LC Analysis of Aliphatic Primary Amines and Diamines After Derivatization with 2,6-Dimethyl-4-quinolinecarboxylic Acid N-Hydroxysuccinimide Ester
A method for sensitive simultaneous analysis of aliphatic primary amines and diamines has been developed and validated. The compounds were analyzed by reversed-phase high-performance liquid chromatography afte...
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Article
Isotope edited product ion assignment by α-N labeling of peptides with [2H3(50%)]2,4-Dinitrofluorobenzene
An isotopic modification of Sanger’s method for identifying peptide N-termini has been developed to assist peptide sequencing by tandem mass spectrometry. Tryptic peptides, such as Val-His-Leu-Thr-Pro-Val-Glu-...