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  1. Article

    Open Access

    CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-γ production by CD4+ T cells

    The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an impo...

    Chenhong Zheng, Shulei Yin, Yang Yang, Yizhi Yu… in Cellular & Molecular Immunology (2018)

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  2. No Access

    Article

    Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

    NF-κB activity is regulated by multiple ubiquitin-dependent regulatory steps. Cao and colleagues show that the rhomboid protein Rhbdd3 recognizes K27-linked ubiquitin and prevents IL-6-mediated autoimmunity by...

    Juan Liu, Chaofeng Han, Bin **e, Yue Wu, Shuxun Liu, Kun Chen… in Nature Immunology (2014)

  3. No Access

    Article

    Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway

    Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. ...

    Yuejuan Zheng, Yang Yang, Yuhu Li, Limin Xu, Yi Wang… in Cellular & Molecular Immunology (2013)

  4. Article

    Correction: Corrigendum: Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

    Nat. Immunol. 9, 542–550 (2008); published online 6 April 2008; corrected after print 22 December 2010 In the version of this article initially published, the actin loading control in Figure 6b (left) was inco...

    Huazhang An, ** Hou, Jun Zhou, Wei Zhao, Hongmei Xu, Yuejuan Zheng… in Nature Immunology (2011)

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    Article

    Cloning and Characterization of DULP, a Novel Ubiquitin-Like Molecule from Human Dendritic Cells

    We identified a novel ubiquitin-like molecule DULP from human dendritic cells. DULP contains a domain that shares 26% identity and 34% similarity with ubiquitin, and it possesses the corresponding Ile-44 hydro...

    Guoyan Liu, Shuxun Liu, ** Li, Ling Tang, Yanmei Han… in Cellular & Molecular Immunology (2009)

  6. No Access

    Article

    Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

    Unbalanced production of proinflammatory cytokines and type I interferons in immune responses may lead to immunopathology; thus, the mechanisms that ensure the beneficial production of proinflammatory cytokine...

    Huazhang An, ** Hou, Jun Zhou, Wei Zhao, Hongmei Xu, Yuejuan Zheng… in Nature Immunology (2008)

  7. No Access

    Article

    Enhanced antitumor effect of EGF R–targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection

    One of the major obstacles in current cancer gene therapy is the lack of a gene delivery system with high efficiency and targetability. In this paper, a nonviral gene delivery system GE7, which was designed to...

    **ang Liu, Peikun Tian, Yizhi Yu, Ming Yao, Xuetao Cao, Jianren Gu in Cancer Gene Therapy (2002)