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Open AccessLoss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer
Immunotherapy has been widely utilized in multiple tumors, however, its efficacy in the treatment of triple-negative breast cancers (TNBC) is still being challenged. Meanwhile, functions and mechanisms of RNA ...
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Article
CD63 acts as a functional marker in maintaining hematopoietic stem cell quiescence through supporting TGFβ signaling in mice
Hematopoietic stem cell (HSC) fate is tightly controlled by various regulators, whereas the underlying mechanism has not been fully uncovered due to the high heterogeneity of these populations. In this study, ...
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Article
Open AccessCAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway
With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the...
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Article
Open AccessFunctions of p53 in pluripotent stem cells
Pluripotent stem cells (PSCs) are capable of unlimited self-renewal in culture and differentiation into all functional cell types in the body, and thus hold great promise for regenerative medicine. To achieve ...
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Article
Open AccessCore pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer
Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulatio...
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Article
Open AccessA miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1
The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclea...
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Open AccessObacunone activates the Nrf2-dependent antioxidant responses
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Open AccessFunctional analysis of the acetylation of human p53 in DNA damage responses
As a critical tumor suppressor, p53 is inactivated in human cancer cells by somatic gene mutation or disruption of pathways required for its activation. Therefore, it is critical to elucidate the mechanism und...
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Open AccessHomologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template
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Open AccessGenetic approach to track neural cell fate decisions using human embryonic stem cells
With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, human embryonic stem cells (hESCs) hold great promise in human cell therapy. However, there are lim...
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Article
The genomic stability of induced pluripotent stem cells
With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of human patients with defi...
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Regulation of p53 responses by post-translational modifications