9 Result(s)

Article

CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway

With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the...

Shuxiang Xu, **chul Kim, Qingshuang Tang, Qu Chen, **gfeng Liu, Yang Xu… in Protein & Cell (2020)

Article

Functions of p53 in pluripotent stem cells

Pluripotent stem cells (PSCs) are capable of unlimited self-renewal in culture and differentiation into all functional cell types in the body, and thus hold great promise for regenerative medicine. To achieve ...

Xuemei Fu, Shouhai Wu, Bo Li, Yang Xu, **gfeng Liu in Protein & Cell (2020)

Article

Core pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer

Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulatio...

Lili Yu, Kai-yuan Ji, Jian Zhang, Yanxia Xu, Yue Ying, Taoyi Mai… in Protein & Cell (2019)

Article

A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1

The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclea...

Youqin Xu, Kaiyuan Ji, Meng Wu, Bingtao Hao, Kai-tai Yao, Yang Xu in Protein & Cell (2019)

Article

Obacunone activates the Nrf2-dependent antioxidant responses

Shengmei Xu, Weimin Chen, Qingfeng **e, Yang Xu in Protein & Cell (2016)

Article

Functional analysis of the acetylation of human p53 in DNA damage responses

As a critical tumor suppressor, p53 is inactivated in human cancer cells by somatic gene mutation or disruption of pathways required for its activation. Therefore, it is critical to elucidate the mechanism und...

Sun-Ku Chung, Shengyun Zhu, Yang Xu, Xuemei Fu in Protein & Cell (2014)

Article

Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template

Zhili Rong, Shengyun Zhu, Yang Xu, Xuemei Fu in Protein & Cell (2014)

Article

Genetic approach to track neural cell fate decisions using human embryonic stem cells

With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, human embryonic stem cells (hESCs) hold great promise in human cell therapy. However, there are lim...

Xuemei Fu, Zhili Rong, Shengyun Zhu, **aocheng Wang, Yang Xu… in Protein & Cell (2014)

Article

The genomic stability of induced pluripotent stem cells

With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of human patients with defi...

Zhao Chen, Tongbiao Zhao, Yang Xu in Protein & Cell (2012)