68 Result(s)

Article

A novel ACE inhibitory peptide from Pelodiscus sinensis Wiegmann meat water-soluble protein hydrolysate

Pelodiscus sinensis meat is a nutritional food and tonic with angiotensin-converting enzyme (ACE) inhibitory activities. To identify the bioactive substances responsible, several bioinformatics methods were integ...

Pengying Liao, Huayu Liu, Xueqin Sun, **nrui Zhang, Miao Zhang, **anyou Wang… in Amino Acids (2024)

Article

Structural basis for human Ca_v3.2 inhibition by selective antagonists

The Ca_v3.2 subtype of T-type calcium channels has been targeted for develo** analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM structures of Ca_v3.2 alone and in compl...

Jian Huang, **ao Fan, Xueqin **, Chen Lyu, Qinmeng Guo, Tao Liu… in Cell Research (2024)

Article

Recurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth

The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...

Fei Tang, Zhonghua Wang, Yan Sun, Linlin Fan, Yun Yang, Xueqin Guo… in BMC Genomics (2024)

Article

Identification and characterization of whole blood gene expression and splicing quantitative trait loci during early to mid-lactation of dairy cattle

Characterization of regulatory variants (e.g., gene expression quantitative trait loci, eQTL; gene splicing QTL, sQTL) is crucial for biologically interpreting molecular mechanisms underlying loci associated w...

Yongjie Tang, **ning Zhang, Wenlong Li, Xueqin Liu, Siqian Chen, Siyuan Mi… in BMC Genomics (2024)

Article

Genome-wide identification and expression pattern analysis of the Aux/IAA (auxin/indole-3-acetic acid) gene family in alfalfa (Medicago sativa) and the potential functions under drought stress

Auxin/induced-3-acetic acid (Aux/IAA) is an important plant hormone that affects plant growth and resistance to abiotic stresses. Drought stress is a vital factor in reducing plant biomass yield and production...

**qing Zhang, Shuxia Li, Xueqin Gao, Yaling Liu, BingZhe Fu in BMC Genomics (2024)

Article

Identification of genomic characteristics and selective signals in Guizhou black goat

Guizhou black goat is one of the indigenous black goat breeds in the southwest region of Guizhou, China, which is an ordinary goat for mutton production. They are characterized by moderate body size, black coa...

Lingle Chang, Yundi Zheng, Sheng Li, ** Niu, Shihui Huang, Qingmeng Long… in BMC Genomics (2024)

Article

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and developmen...

Jie Zhao, Chen Yao, Yongqin Qin, Hanyong Zhu, Hui Guo, Binbin Ji… in Cell Death & Disease (2024)

Article

Genome-wide identification of B-box zinc finger (BBX) gene family in Medicago sativa and their roles in abiotic stress responses

B-box (BBX) family is a class of zinc finger transcription factors (TFs) that play essential roles in regulating plant growth, development, as well as abiotic stress. However, no systematic analysis of BBX genes ...

Shuxia Li, Shuaiqi Guo, Xueqin Gao, **aotong Wang, Yaling Liu, **g Wang… in BMC Genomics (2024)

Article

Retraction Note: Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7

Binbin Yu, Kailiu Wu, Xu Wang, Jianjun Zhang, Lizhen Wang… in Cell Death & Disease (2024)

Article

Genome-wide association study reveals serovar-associated genetic loci in Riemerella anatipestifer

The disease caused by Riemerella anatipestifer (R. anatipestifer, RA) results in large economic losses to the global duck industry every year. Serovar-related genomic variation, such as the O-antigen and capsular...

Zhishuang Yang, Xueqin Yang, Mingshu Wang, Renyong Jia, Shun Chen… in BMC Genomics (2024)

Article

Publisher Correction: Interim survival analysis of the randomized phase III GEMSTONE-302 trial: sugemalimab or placebo plus chemotherapy as first-line treatment for metastatic NSCLC

Caicun Zhou, Zi** Wang, Meili Sun, Lejie Cao, Zhiyong Ma, Rong Wu… in Nature Cancer (2024)

Article

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling

Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive. Here, we found that cyclic GMP-AMP synthase (cGAS, a cyt...

Zhangchu **, Zhehua Shao, Shiyi Yang, Anyi Guo, Yinling Han… in Cell Death & Disease (2023)

Article

Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse

Li-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53. It is a severe cancer predisposition syndrome with a poor prognosis, partly due to the frequent d...

Jiabing Li, Shujun **ao, Fangfang Shi, Huaxin Song, Jiaqi Wu… in Cell Death & Disease (2023)

Article

Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia

A molecular surveillance of tick-borne diseases was performed in Hulunbuir City, Inner Mongolia. A total of 149 ticks including three species (Ixodes persulcatus, Haemaphysalis concinna, and Dermacentor silvarum)...

Junhua Tian, **g Liu, Hongqing Zhao, **aomin Chen, Xueqin Geng… in BMC Microbiology (2023)

Article

The panda-derived Lactiplantibacillus plantarum BSG201683 improves LPS-induced intestinal inflammation and epithelial barrier disruption in vitro

Captive pandas are suffering from intestinal infection due to intestinal microbiota characterized by a high abundance of Enterobacteriaceae induced by long-term captivity. Probiotic supplements showed improvement...

Yi Zhou, Ling Duan, Yan Zeng, Xu Song, Kangcheng Pan, Lili Niu, Yang Pu… in BMC Microbiology (2023)

Article

Publisher Correction: Performance and effectiveness of hepatocellular carcinoma screening in individuals with HBsAg seropositivity in China: a multicenter prospective study

Hongmei Zeng, Maomao Cao, Changfa **a, Dongmei Wang, Kun Chen, Zheng Zhu… in Nature Cancer (2023)

Article

Molecular regulatory mechanism of key LncRNAs in subclinical mastitic cows with folic acid supplementation

Folic acid is a water-soluble B vitamin (B9), which is closely related to the body’s immune and other metabolic pathways. The folic acid synthesized by rumen microbes has been unable to meet the needs of high-...

Xueqin Liu, Siyuan Mi, Wenlong Li, **ning Zhang, Serafino M. A. Augustino… in BMC Genomics (2023)

Article

Anti-Klebsiella pneumoniae activity of secondary metabolism of Achromobacter from the intestine of Periplaneta americana

Klebsiella pneumoniae is one of the main pathogens of clinical isolation and nosocomial infections, as K. pneumoniae show broad-spectrum resistance to β-lactam and carbapenem antibiotics. It is emerging clinical ...

Yan Ma, ** Guo, Xueqin Chen, Minhua Xu, Wenbin Liu, **aobao ** in BMC Microbiology (2023)