22 Result(s)
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William J. Kelly
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Open AccessHydrogen and formate production and utilisation in the rumen and the human colon
Molecular hydrogen (H2) and formate (HCOO−) are metabolic end products of many primary fermenters in the mammalian gut. Both play a vital role in fermentation where they are electron sinks for individual microbes...
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Glucocorticoids and immune checkpoint inhibitors in glioblastoma
Immunotherapy, activation of the immune system to target tumor cells, represents a paradigm shift in the treatment of cancer. Immune checkpoint therapies, which target immunomodulatory molecules expressed on T...
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Open AccessOccurrence and expression of genes encoding methyl-compound production in rumen bacteria
Digestive processes in the rumen lead to the release of methyl-compounds, mainly methanol and methylamines, which are used by methyltrophic methanogens to form methane, an important agricultural greenhouse gas...
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Development of a Computational Fluid Dynamics Model for Scaling-up Ambr Bioreactors
It is known that process scaling-up has always been a challenge in biopharmaceutical and food industry. In recent years, newly emerging microscale bioreactors like Ambr15 and Ambr250 have attracted significant...
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Open AccessCultivation and sequencing of rumen microbiome members from the Hungate1000 Collection
Rumen microbiome biology gets a boost with the release of 410 high-quality reference genomes from the Hungate1000 project.
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Open AccessClinical activity of nivolumab in patients with non-clear cell renal cell carcinoma
Nivolumab is approved for patients with metastatic renal cell carcinoma (mRCC) refractory to prior antiangiogenic therapy. The clinical activity of nivolumab in patients with non-clear cell RCC subtypes remain...
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Open AccessThe complete genome sequence of the rumen bacterium Butyrivibrio hungatei MB2003
Butyrivibrio hungatei MB2003 was isolated from the plant-adherent fraction of rumen contents from a pasture-grazed New Zealand dairy cow, and was selected for genome sequencing in order t...
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Open AccessGene and transcript abundances of bacterial type III secretion systems from the rumen microbiome are correlated with methane yield in sheep
Ruminants are important contributors to global methane emissions via microbial fermentation in their reticulo-rumens. This study is part of a larger program, characterising the rumen microbiomes of sheep which...
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Evaluation of Sugars and Bio-oil Production Using Lead Contaminated Switchgrass Feedstock
A combination of biochemical and thermochemical process to produce sugars and bio-oil by using switchgrass which was grown in lead contaminated soil was studied. Four different process routes which involve fas...
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Open AccessThe complete genome sequence of the methanogenic archaeon ISO4-H5 provides insights into the methylotrophic lifestyle of a ruminal representative of the Methanomassiliicoccales
Methane emissions from agriculture represent around 9 % of global anthropogenic greenhouse emissions. The single largest source of this methane is animal enteric fermentation, predominantly from ruminant lives...
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Open AccessThe complete genome sequence of the rumen methanogen Methanobrevibacter millerae SM9
Methanobrevibacter millerae SM9 was isolated from the rumen of a sheep maintained on a fresh forage diet, and its genome has been sequenced to provide information on the phylogenetic dive...
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Open AccessGenomic analysis of three Bifidobacterium species isolated from the calf gastrointestinal tract
Ruminant animals contribute significantly to the global value of agriculture and rely on a complex microbial community for efficient digestion. However, little is known of how this microbial-host relationship ...
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Open AccessThe complete genome sequence of Eubacterium limosum SA11, a metabolically versatile rumen acetogen
Acetogens are a specialized group of anaerobic bacteria able to produce acetate from CO2 and H2 via the Wood–Ljungdahl pathway. In some gut environments acetogens can compete with methanogens for H2, and as a res...
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Open AccessThe complete genome sequence of the rumen methanogen Methanosarcina barkeri CM1
Methanosarcina species are the most metabolically versatile of the methanogenic Archaea and can obtain energy for growth by producing methane via the hydrogenotrophic, acetoclastic or met...
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Open AccessThe complete genome sequence of the rumen methanogen Methanobacterium formicicum BRM9
Methanobacterium formicicum BRM9 was isolated from the rumen of a New Zealand Friesan cow grazing a ryegrass/clover pasture, and its genome has been sequenced to provide information on the phylogenetic diversity...
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Open AccessLactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation
Intestinal barrier function is important for preserving health, as a compromised barrier allows antigen entry and can induce inflammatory diseases. Probiotic bacteria can play a role in enhancing intestinal ba...
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Optimal operation of high-pressure homogenization for intracellular product recovery
An optimal control methodology for the homogenization of bacterial cells to recover intracellular products is presented. A Fluent computational fluid dynamics (CFD) model is used to quantify the hydrodynamic f...
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Molecular cloning and expression of multiple cellulase genes of Ruminococcus flavefaciens strain 186 in Escherichia coli
Cellulase genes of the ruminant micro-organism Ruminococcus flavefaciens strain 186 have been cloned and expressed in Escherichia coli using the bacteriophage vector λNM1149. Twenty-six clones showed expression o...
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Isolation and characterization of plasmid DNA fromRuminococcus
A method has been developed, utilizing mutanolysin and proteinase K, for the rapid lysis of strains of the rumen cellulolytic bacteriumRuminococcus. This has enabled bacterial chromosomal and plasmid DNA to be is...
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Performance differences among the intervals in forced-choice tasks
Listeners were tested on a variety of three-interval, forced-choice auditory detection and discrimination tasks. Differences in performance were frequently found among the three intervals, with best performanc...
