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  1. Article

    Open Access

    Sitafloxacin reduces tumor necrosis factor alpha (TNFα) converting enzyme (TACE) phosphorylation and activity to inhibit TNFα release from lipopolysaccharide-stimulated THP-1 cells

    Sepsis is a systemic reaction to an infection and resulting in excessive production of inflammatory cytokines and chemokines. It sometimes results in septic shock. The present study aimed to identify quinolone...

    Ippei Sakamaki, Michika Fukushi, Wakana Ohashi, Yukie Tanaka… in Scientific Reports (2021)

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  2. Article

    Open Access

    Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

    Intestinal microbiota-derived metabolites have biological importance for the host. Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota and regulate multiple biological proc...

    Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi… in Nature Communications (2021)

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  3. No Access

    Article

    Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

    Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play di...

    Wakana Ohashi, Takafumi Hara, Teruhisa Takagishi… in Digestive Diseases and Sciences (2019)

  4. Article

    Open Access

    Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

    Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency and skin disorders. Various cells including mast cells release Zn-containing granules when activated; however, the biological role ...

    Keigo Nishida, Aiko Hasegawa, Satoru Yamasaki, Ryota Uchida… in Scientific Reports (2019)

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  5. Article

    Open Access

    Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis

    Histamine assumes an important role as a major mediator in various pathologic disorders associated with inflammation and immune reactions. However, the involvement of histamine in the pathological conditions a...

    Mizuki Hattori, Mitsuaki Yamazaki, Wakana Ohashi… in Intensive Care Medicine Experimental (2016)

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  6. No Access

    Article

    Letter to the Editor: Backbone 1H, 13C and 15N resonance assignments for the Mg2+-bound form of the Ca2+-binding photoprotein aequorin

    Wakana Ohashi, Satoshi Inouye, Toshio Yamazaki… in Journal of Biomolecular NMR (2005)