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  1. No Access

    Article

    The potential and challenges of nanopore sequencing

    A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. The nanopore provides a ...

    Daniel Branton, David W Deamer, Andre Marziali, Hagan Bayley… in Nature Biotechnology (2008)

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    Article

    Solid-state nanopore fabrication by automated controlled breakdown

    Solid-state nanopores are now well established as single-biomolecule sensors that hold great promise as sensing elements in diagnostic and sequencing applications. However, until recently this promise has been...

    Matthew Waugh, Kyle Briggs, Dylan Gunn, Mathieu Gibeault, Simon King… in Nature Protocols (2020)

  3. Article

    Open Access

    Serum neurofilament light chain predicts long term clinical outcomes in multiple sclerosis

    Serum neurofilament light chain (NfL) is emerging as an important biomarker in multiple sclerosis (MS). Our objective was to evaluate the prognostic value of serum NfL levels obtained close to the time of MS o...

    Simon Thebault, Mohammad Abdoli, Seyed-Mohammad Fereshtehnejad… in Scientific Reports (2020)

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  4. Article

    No small matter

    The confined geometry of nanopores enables a wealth of chemistry and analysis to be conducted at the single-molecule scale. Yi-Lun Ying, Aleksandar P. Ivanov and Vincent Tabard-Cossa report on recent developme...

    Yi-Lun Ying, Aleksandar P. Ivanov, Vincent Tabard-Cossa in Nature Chemistry (2021)

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  5. Article

    Open Access

    Digital immunoassay for biomarker concentration quantification using solid-state nanopores

    Single-molecule counting is the most accurate and precise method for determining the concentration of a biomarker in solution and is leading to the emergence of digital diagnostic platforms enabling precision ...

    Liqun He, Daniel R. Tessier, Kyle Briggs, Matthaios Tsangaris… in Nature Communications (2021)

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    Article

    Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy

    Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of the SMN1 gene and low SMN protein levels. Although lower motor neurons are a primary target, there is evidence that peripheral organ defe...

    Aoife Reilly, Marc-Olivier Deguise, Ariane Beauvais, Rebecca Yaworski… in Gene Therapy (2022)

  7. No Access

    Article

    Elucidating the dynamics of polymer transport through nanopores using asymmetric salt concentrations

    While notable progress has been made in recent years both experimentally and theoretically in understanding the highly complex dynamics of polymer capture and transport through nanopores, there remains signifi...

    Martin Charron, Lucas Philipp, Liqun He, Vincent Tabard-Cossa in Nano Research (2022)