35 Result(s)

Article

Treatment with One Dose of Reltecimod is Superior to Two Doses in Mouse Models of Lethal Infection

Soft-tissue bacterial infection can progress to severe sepsis and septic shock as a result of a disproportionate inflammatory response, characterized by an excessive release of cytokines and influx of immune c...

Rotem Edgar, Margarite L. Tarrio… in International Journal of Peptide Research … (2020)

Article

Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis

In Gram-negative bacterial sepsis, production of excess pro-inflammatory cytokines results in hyperinflammation and tissue injury. Anti-inflammatory cytokines such as IL-10 inhibit inflammation and enhance tis...

Pragnya Das, Santosh K. Panda, Beamon Agarwal, Sumita Behera… in Scientific Reports (2019)

Article

Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acq...

Tobias Welte, R. Phillip Dellinger, Henning Ebelt, Miguel Ferrer… in Intensive Care Medicine (2018)

Article

Age, exercise, and the outcome of sepsis

We report on the increasingly important need to diagnose and care for the elderly with sepsis as a distinct patient population. We share an overview of age-related changes in sepsis physiology and the potentia...

Debasree Banerjee, Steven M. Opal in Critical Care (2017)

Article

Should all septic patients be given systemic anticoagulation? No

Tom van der Poll, Steven M. Opal in Intensive Care Medicine (2017)

Article

Non-antibiotic treatments for bacterial diseases in an era of progressive antibiotic resistance

The emergence of multi-drug resistant (MDR) microbial pathogens threatens the very foundation upon which standard antibacterial chemotherapy is based. We must consider non-antibiotic solutions to manage invasi...

Steven M. Opal in Critical Care (2016)

Article

Sepsis and septic shock

For more than two decades, sepsis was defined as a microbial infection that produces fever (or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now increasingly being considered a d...

Richard S. Hotchkiss, Lyle L. Moldawer, Steven M. Opal… in Nature Reviews Disease Primers (2016)

Article

Sepsis in the Severely Immunocompromised Patient

The prevention and treatment of sepsis in the immunocompromised host present a challenging array of diagnostic and management issues. The neutropenic patient has a primary defect in innate immune responses and...

Andre C. Kalil, Steven M. Opal in Current Infectious Disease Reports (2015)

Article

The dysfunctional host response to influenza A H7N9: a potential treatment option?

The newly emerging human pathogen influenza A H7N9 represents a potentially major threat to human health. The virus was first shown to be pathogenic in humans in 2013, and outbreaks continue to occur in China ...

Steven M Opal, David S Fedson in Critical Care (2014)

Article

Over-distension of the airways by mechanical ventilation in the elderly: adding insult to injury

Setzer and colleagues demonstrate that older animals are more susceptible to ventilator-induced lung injury than young animals and develop a more pronounced local and systemic cytokine response to high tidal v...

Aurora Pop-Vicas, Steven M Opal in Critical Care (2013)

Article

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

To provide an update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008.

R. P. Dellinger, Mitchell M. Levy, Andrew Rhodes… in Intensive Care Medicine (2013)

Article

Clinical review: The role of biomarkers in the diagnosis and management of community-acquired pneumonia

In patients with community-acquired pneumonia, traditional criteria of infection based on clinical signs and symptoms, clinical scoring systems, and general inflammatory indicators (for example, leukocytosis, ...

Mirjam Christ-Crain, Steven M Opal in Critical Care (2010)

Article

Year in review 2008: Critical Care - sepsis

The present report highlights the most important papers appearing in Critical Care and other major journals about severe sepsis, the systemic inflammatory response and multiorgan dysfunction over the past year. A...

Steven M Opal, Steven P LaRosa in Critical Care (2009)

Article

Coming soon to an ICU near you: severe pandemic influenza in ICU patients in Spain

A novel strain of swine influenza A H1N1 has already disseminated worldwide and has become a major clinical problem for intensive care units in selected areas. Many regions in the southern hemisphere are curre...

Steven M Opal in Critical Care (2009)

Article

Swine flu, pandemics, and critical care

Steven M Opal in Critical Care (2009)

Article

A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia

The purpose of this analysis was to determine the potential efficacy of recombinant human tissue factor pathway inhibitor (tifacogin) in a subpopulation of patients with community-acquired pneumonia (CAP) from...

Pierre-François Laterre, Steven M Opal, Edward Abraham, Steven P LaRosa… in Critical Care (2009)