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Article
Prolonged Benefit of Reltecimod Despite Short Plasma Half-Life
Reltecimod (previously AB103 or p2TA) is a short-peptide mimetic of the CD28 costimulatory receptor on T cells that attenuates CD28/B7-2 signaling, which are responsible for the hyperinflammatory response that is...
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Article
Treatment with One Dose of Reltecimod is Superior to Two Doses in Mouse Models of Lethal Infection
Soft-tissue bacterial infection can progress to severe sepsis and septic shock as a result of a disproportionate inflammatory response, characterized by an excessive release of cytokines and influx of immune c...
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Article
Phenotypic heterogeneity in a bacteriophage population only appears as stress-induced mutagenesis
Stress-induced mutagenesis has been studied in cancer cells, yeast, bacteria, and archaea, but not in viruses. In a recent publication, we present a bacteriophage model showing an apparent stress-induced mutag...
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Article
Natural selection underlies apparent stress-induced mutagenesis in a bacteriophage infection model
The emergence of mutations following growth-limiting conditions underlies bacterial drug resistance, viral escape from the immune system and fundamental evolution-driven events. Intriguingly, whether mutations...
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Article
CRISPR adaptation biases explain preference for acquisition of foreign DNA
CRISPR–Cas (clustered, regularly interspaced short palindromic repeats coupled with CRISPR-associated proteins) is a bacterial immunity system that protects against invading phages or plasmids. In the process ...
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Protocol
Using the CRISPR-Cas System to Positively Select Mutants in Genes Essential for Its Function
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated proteins (Cas) comprise a prokaryotic adaptive defense system against foreign nucleic acids. This defense is mediate...
