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Article
Open AccessMutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD
The GGGGCC hexanucleotide repeat expansion mutation in the chromosome 9 open reading frame 72 (C9orf72) gene is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). In t...
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Article
Open AccessImpulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1
Impulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified...
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Article
Protamine is an inhibitor of angiogenesis
Protamine is shown to be a specific inhibitor of angiogenesis. The compound inhibits the capillary proliferation observed in embryogenesis, inflammation, certain immune reactions and the growth of solid tumours.