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  1. No Access

    Article

    Post-translational control of T cell development by the ESCRT protein CHMP5

    Thymocytes must undergo positive selection to survive and emigrate to the periphery as mature T cells. Glimcher and colleagues identify CHMP5 as a TCR-sensitive regulator of positive selection that acts by pre...

    Stanley Adoro, Kwang Hwan Park, Sarah E Bettigole, Raphael Lis… in Nature Immunology (2017)

  2. No Access

    Article

    The transcription factor XBP1 is selectively required for eosinophil differentiation

    The transcription factor XBP1 is associated with endoplasmic reticulum stress. Glimcher and colleagues show that XBP1 is expressed during eosinophil differentiation and is uniquely required for the production ...

    Sarah E Bettigole, Raphael Lis, Stanley Adoro, Ann-Hwee Lee… in Nature Immunology (2015)

  3. No Access

    Article

    A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

    Transcription factor Foxp3 is essential for the development and function of regulatory T cells, but it does not act in isolation. Benoist and colleagues identify a quintet of factors that facilitate transcript...

    Wenxian Fu, Ayla Ergun, Ting Lu, Jonathan A Hill, Sokol Haxhinasto… in Nature Immunology (2012)

  4. No Access

    Article

    Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

    Whether CD8-lineage specification and CD8+ T cell differentiation is dependent on intrathymic cytokines signaling is unclear. Singer and co-workers show that interleukin 7 specifies CD8-lineage choice and promote...

    Jung-Hyun Park, Stanley Adoro, Terry Guinter, Batu Erman, Amala S Alag… in Nature Immunology (2010)

  5. No Access

    Article

    Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

  6. Develo** CD4+CD8+ double positive (DP) thymocytes differentiate either into CD4+ helper or CD8+ cytotoxic T cells, depending on the MHC-restriction specifici...

    7. Alfred Singer, Stanley Adoro, Jung-Hyun Park in Nature Reviews Immunology (2008)

  7. No Access

    Article

    'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

    T cell immunity requires the long-term survival of T cells that are capable of recognizing self antigens but are not overtly autoreactive. How this balance is achieved remains incompletely understood. Here we ...

    Jung-Hyun Park, Stanley Adoro, Philip J Lucas, Sophia D Sarafova… in Nature Immunology (2007)

  8. No Access

    Article

    Antimalarial Drugs Exacerbate Rat Liver Microsomal Lipid Peroxidation in the Presence of Oxidants

    The study was undertaken to evaluate the effect of prior treatment of rats with the antimalarial drugs amodiaquine (AQ) mefloquine (MQ) and halofantrine (HF) on rat liver microsomal lipid peroxidation in the p...

    E. Olatunde Farombi, Stanley Adoro, Samuel Uhunmwangho in Bioscience Reports (2001)