889 Result(s)
-
Article
Über die blutdrucksteigernde Wirkung des Histamins bei Katzen mit und ohne Nebennieren
Die Blutdrucksteigerung, die einer zweiten sehr großen Histaminmenge folgt, läßt sich auch an nebennierenlosen Katzen erhalten und beruht daher auf einer Gefäßverengerung im großen Kreislauf, wie Dale und Laid...
-
Article
A laboratory investigation of the effect of alcohol upon attempts to reach agreement
-
Article
The mechanism whereby growth hormone-release inhibiting hormone (somatostatin) inhibits food stimulated gastric acid secretion in the cat
Growth hormone-release inhibiting hormone (somatostatin) inhibits the gastric acid response to food in concious cats. We have confirmed that this tetradecapeptide blocks the food stimulated gastrin release. Ho...
-
Article
Comparison of the inhibition of histamine-and pentagastrin-stimulated gastric acid secretion by somatostatin in the cat
The effect of cyclic somatostatin on pentagastrin-and histamine-stimulated gastric acid secretion in conscious cats was studied. Evidence is produced that somatostatin competitively inhibits pentagastrin-stimu...
-
Article
Cholinergic and histaminergic involvement in the growth hormone releasing effect of an enkephalin analog FK 33-824 in man
Studies were performed in healthy subjects to ascertain the neurotransmitter systems involved in the growth hormone (GH)-releasing effect of the potent enkephalin analog FK 33-824. Concomitant evaluation of pr...
-
Article
The effect of nootropil in a patient on warfarin
-
Article
In vitro inhibitory activities of urea analogues on bacterial urease
Twenty six urea analogues, most of which have already been approved for human use, were tested for their antiurease activityin vitro. Cell-free extracts obtained from a clinical isolate ofProteus mirabilis was us...
-
Article
Potentiation of the antitumor activity of cisplatin in mice by 3-aminobenzamide and nicotinamide
3-Aminobenzamide (3AB) and nicotinamide (NA), inhibitors of adenosine-ribose transferase (ADPRT), potentiated the antitumor activity of cisplatin (DDP) on Ehrlich ascites carcinoma in mice. The mean survival t...
-
Article
Porfiromycin disposition in oxygen-modulated P388 cells
The cytotoxicity, metabolism, and DNA alkylation of porfiromycin (PFM) under aerobic and hypoxic conditions were evaluated in P388 murine leukemia cells. Clonogenic assays showed that the IC50 value for a 1-h exp...
-
Article
Clinical pharmacology of pravastatin, a selective inhibitor of HMG-CoA reductase
Pravastatin, lovastatin and simvastatin are HMG-CoA reductase inhibitors with very similar structures. However, minor substitutions in the decalin ring have resulted in major differences in physicochemical, ph...
-
Article
Clinical pharmacology of pravastatin, a selective inhibitor of HMG-CoA reductase
Pravastatin, lovastatin and simvastatin are HMG-CoA reductase inhibitors with very similar structures. However, minor substitutions in the decalin ring have resulted in major differences in physicochemical, ph...
-
Article
The role of NAD(P)H: quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells
A mitomycin C (MMC)- and porfiromycin (PFM)-resistant subline of the HCT 116 human coloncancer cell line was isolated after repeated exposure of HCT 116 cells to increasing concentrations of MMC under aerobic ...
-
Article
Intrinsic resistance to anticancer agents in the murine pancreatic adenocarcinoma PANC02
PANC02 is a ductal adenocarcinoma of the pancreas that is resistant to every known class of clinically active antitumor agent. To study the mechanism(s) underlying the intrinsic drug resistance of this tumor, ...
-
Article
Mechanisms of resistance to 6-thioguanine in a murine pancreatic tumor
PANC02 is a unique experimental animal tumor that fails to respond significantly to any known clinically active antitumor agent. In this regard, the murine ductal adenocarcinoma resembles its human counterpart...
-
Article
Neutrophil adherence to airway epithelium is reduced by antibodies to the leukocyte CD11/CD18 complex
Airway inflammation, including neutrophil influx is commonly seen in human pulmonary diseases. We developed an in vitro system where the adherence of neutrophils to bronchial epithelial cells could be examined...
-
Article
Hydrogen peroxide induces DNA single strand breaks in respiratory epithelial cells
The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We e...
-
Article
Alveolar Permeability Enhancement by Oleic Acid and Related Fatty Acids: Evidence for a Calcium-Dependent Mechanism
Pulmonary exposure to oleic acid (OA) is associated with permeability alterations and cellular damage; however, the exact relationship between these two effects has not been clearly established. Using cultured...
-
Article
Purinoceptor-stimulated phosphoinositide hydrolysis in Madin-Darby canine kidney (MDCK) cells
Extracellular nucleotides, acting through P2-purinoceptors, have been implicated in the regulation of ion transport in epithelia, including Madin-Darby canine kidney (MDCK) cells. In this study, experiments were ...
-
Article
Cocaine Pharmacokinetics/ Pharmacodynamics in Awake Freely Moving Rats
-
Article
In vitro study on the involvement of CYP1A2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol
Objective: To investigate in vitro which CYP isoforms (CYP1A2, CYP2D6 and CYP3A4) are involved in the biotransformation of haloperidol (HAL) and reduced haloperidol (RHAL).
