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Comparison of the inhibition of histamine-and pentagastrin-stimulated gastric acid secretion by somatostatin in the cat

  • Histamine and Kinins
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Abstract

The effect of cyclic somatostatin on pentagastrin-and histamine-stimulated gastric acid secretion in conscious cats was studied. Evidence is produced that somatostatin competitively inhibits pentagastrin-stimulated gastric acid secretion whereas it inhibits histamine-stimulated secretion by a mechanism which is not competitive in nature. The vagus nerves seem to be involved in the mode of action of somatostatin as the inhibitory effects are greater in vagotomized than in vagus intact animals.

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Author notes

  1. Margitta Albinus

    Present address: Department of Pharmacology, University of Tubingen, West Germany

  2. Antonio Gomez-Pan

    Present address: Servicio de Neuroendocrinologia, Depto. de Endocrinologia, Pabellon 8, Facultad de Medicina, Ciudad Universitaria, Madrid 3, Spain

Authors and Affiliations

  1. Department of Physiology, University of Newcastle upon Tyne, England

    Margitta Albinus & J. David Reed

  2. Endocrine Unit, Department of Medicine, University of Newcastle upon Tyne, England

    Antonio Gomez-Pan

  3. Veterans Administration Hospital and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA

    Andrew V. Schally & David H. Coy

Authors
  1. Margitta Albinus
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  2. J. David Reed
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  3. Antonio Gomez-Pan
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  4. Andrew V. Schally
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  5. David H. Coy
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Albinus, M., Reed, J.D., Gomez-Pan, A. et al. Comparison of the inhibition of histamine-and pentagastrin-stimulated gastric acid secretion by somatostatin in the cat. Agents and Actions 7, 501–506 (1977). https://doi.org/10.1007/BF02111121

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  • DOI: https://doi.org/10.1007/BF02111121

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