413 Result(s)

Article

A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours

Listeria monocytogenes is an intracellular organism that has the unusual ability to live in the cytoplasm of the cell. It is thus a good vector for targeting protein antigens to the cellular arm of the immune res...

Zhen-Kun Pan, Georgios Ikonomidis, Audrey Lazenby, Drew Pardoll… in Nature Medicine (1995)

Article

β-Adrenergic Antagonism Alters the Behavioral and Neurochemical Responses to Cocaine

The effects of the β-adrenergic antagonist propranolol on the locomotor stimulating, neurochemical, and reinforcing effects of cocaine were examined in rats. In Experiment 1, propranolol (1, 3 and 10 mg/kg, IP...

Glenda C Harris, Mohsen A Hedaya, Wei-Jian Pan… in Neuropsychopharmacology (1996)

Article

Erratum: Ion channel properties underlying axonal action potential initiation in pyramidal neurons

Nat. Neurosci. 5, 533–538 (2002) A printer's error introduced an extraneous diagonal line into Fig. 2b on page 534. The correct figure is reproduced below.

Costa M. Colbert, Enhui Pan in Nature Neuroscience (2002)

Article

Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects

Research evidence that corticotropin-releasing factor (CRF) plays a role in the pathophysiology of major depressive disorder (MDD) has accumulated over the past 20 years. The elevation of lumbar cerebrospinal ...

Garth Bissette, Violetta Klimek, Jun Pan, Craig Stockmeier… in Neuropsychopharmacology (2003)

Article

Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats

Chronic food restriction augments the rewarding effect of centrally administered psychostimulant drugs and this effect may involve a previously documented upregulation of D-1 dopamine receptor-mediated MAP kin...

Yan Pan, Yemiliya Berman, Kenneth D Carr in BMC Neuroscience (2004)

Article

Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats

Currently, opioid-based drugs are the most effective pain relievers that are widely used in the treatment of pain. However, the analgesic efficacy of opioids is significantly limited by the development of tole...

Bihua Bie, Zhizhong Z Pan in Molecular Pain (2005)

Article

Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer’s disease

Systems biology offers enormous potential to understand the complexity of human brain aging and neurodegenerative diseases. Proteomics has an important role in these investigations because of its unique streng...

Thomas J. Montine, Randall L. Woltjer, Catherine Pan, Kathleen S. Montine… in NeuroRX (2006)

Article

Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies

Restoration of blood flow following ischemic stroke can be achieved by means of thrombolysis or mechanical recanalization. However, for some patients, reperfusion may exacerbate the injury initially caused by ...

Jie Pan, Angelos-Aristeidis Konstas, Brian Bateman, Girolamo A. Ortolano… in Neuroradiology (2007)

Article

Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells

Many studies have shown that mitochondrial dysfunction, complex I inhibition in particular, is involved in the pathogenesis of Parkinson's disease (PD). Rotenone, a specific inhibitor of mitochondrial complex ...

**ghua **, Jeanne Davis, David Zhu, Daniel T Kashima, Marc Leroueil… in BMC Neuroscience (2007)

Article

Trafficking of central opioid receptors and descending pain inhibition

The delta-opioid receptor (DOR) belongs to the superfamily of G-protein-coupled receptors (GPCRs) with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes ...

Bihua Bie, Zhizhong Z Pan in Molecular Pain (2007)

Article

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

Parkinson's disease (PD) is the most prevalent incurable neurodegenerative movement disorder. Mutations in LRRK2 are associated with both autosomal dominant familial and sporadic forms of PD. LRRK2 encodes a larg...

Danling Wang, Beisha Tang, Guohua Zhao, Qian Pan, Kun **a… in Molecular Neurodegeneration (2008)

Article

Increased Leptin Permeation across the Blood–Brain Barrier after Chronic Alcohol Ingestion

Leptin, a polypeptide mainly produced in the periphery, crosses the blood–brain barrier (BBB) by receptor-mediated transport to exert multiple central nervous system actions including decreased food intake. Th...

Weihong Pan, Misty Barron, Hung Hsuchou, Hong Tu, Abba J Kastin in Neuropsychopharmacology (2008)

Article

FMRI connectivity analysis of acupuncture effects on an amygdala-associated brain network

Recently, increasing evidence has indicated that the primary acupuncture effects are mediated by the central nervous system. However, specific brain networks underpinning these effects remain unclear.

Wei Qin, Jie Tian, Lijun Bai, **aohong Pan, Lin Yang, Peng Chen… in Molecular Pain (2008)

Article

IgCAMs redundantly control axon navigation in Caenorhabditis elegans

Cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) form one of the largest and most diverse families of adhesion molecules and receptors in the nervous system. Many members of this family media...

Valentin Schwarz, Jie Pan, Susanne Voltmer-Irsch, Harald Hutter in Neural Development (2009)

Article

Characterization of Proteasome Inhibition on Astrocytes Cell Cycle

Qing-Guo Ren, Ying Yu, **ang Luo, **e-Min Jie… in Journal of Molecular Neuroscience (2009)

Article

Regulation of cerebrospinal fluid production by caffeine consumption

Caffeine is the most commonly consumed psycho-stimulant in the world. The effects of caffeine on the body have been extensively studied; however, its effect on the structure of the brain has not been investiga...

Myoung-Eun Han, Hak-** Kim, Young-Suk Lee, Dong-Hyun Kim… in BMC Neuroscience (2009)

Article

Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke

Omega-3 polyunsaturated fatty acids are known to have therapeutic potential in several neurological and psychiatric disorders. However, the molecular mechanisms of action underlying these effects are not well ...

Nicolas Blondeau, Carine Nguemeni, David N Debruyne, Marie Piens… in Neuropsychopharmacology (2009)

Article

TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5

Overactivated microglia that cluster at neuritic plaques constantly release neurotoxins, which actively contribute to progressive neurodegeneration in Alzheimer's disease (AD). Therefore, attenuating microglia...

Wei-Chao Huang, Feng-Chang Yen, Feng-Shiun Shie… in Journal of Neuroinflammation (2010)

Article

Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress

The nucleus accumbens (NAc) is a critical component of the reward circuitry, and dysfunction of the NAc may account for anhedonia and other symptoms of depression. Here, we investigated whether alterations in ...

Wei Wang, Dalong Sun, Bin Pan, Christopher J Roberts… in Neuropsychopharmacology (2010)

Article

Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCϵ pathway in dorsal root ganglion neurons

It has been demonstrated that lysophosphatidic acid (LPA) released from injury tissue and transient receptor potential vanilloid 1 (TRPV1) receptor are implicated in the induction of chronic pain. In the prese...

Hai-Li Pan, Yu-Qiu Zhang, Zhi-Qi Zhao in Molecular Pain (2010)