22 Result(s)

Article

RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway

Glucose oxidation via the pentose phosphate pathway serves as the primary cellular mechanism for generating nicotinamide adenine dinucleotide phosphate (NADPH). The central regions of solid tumors typically ex...

Nan Zhang, Lu Dong, Tingting Ning, Feng Du, Mengran Zhao, Junxuan Xu… in Oncogenesis (2024)

Article

Retraction Note: Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Weilong Yao, Shengtao Zhu, Peng Li, Shutian Zhang in Cancer Cell International (2023)

Article

Mucosal Microbiota: Closer to the Pathology, Closer to the Truth?

Sian **e, Shengtao Zhu, Li Min in Digestive Diseases and Sciences (2022)

Article

Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study

The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospect...

Shanshan Wu, Changzheng Yuan, Zhirong Yang, Si Liu, Qian Zhang… in BMC Medicine (2022)

Article

The role of GTPase-activating protein ARHGAP26 in human cancers

Rho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits t...

Lingye Zhang, Anni Zhou, Shengtao Zhu, Li Min… in Molecular and Cellular Biochemistry (2022)

Article

The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer

Exosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Ex...

Zheng Zhao, Gui** Zhao, Shuyue Yang, Shengtao Zhu… in Cancer Cell International (2021)

Article

Combination of Size-Exclusion Chromatography and Ultracentrifugation Improves the Proteomic Profiling of Plasma-Derived Small Extracellular Vesicles

Circulating small extracellular vesicles (sEVs) and its associated proteins are of great interest in the early detection of many diseases. However, there is no gold standard for plasma sEVs isolation, especial...

Rui Wei, Libo Zhao, Guanyi Kong, **ang Liu, Shengtao Zhu… in Biological Procedures Online (2020)

Article

Assessment of prevalence and risk factors of helicobacter pylori infection in an oilfield Community in Hebei, China

Only a paucity of large-scale perspective and cross-sectional studies on H. pylori infection in China have been published. The purpose of this study was to investigate the prevalence and risk factors for H. pylor...

Wenhai Wang, Wei Jiang, Shengtao Zhu, **u**g Sun, Peng Li… in BMC Gastroenterology (2019)

Article

RETRACTED ARTICLE: Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment ...

Weilong Yao, Shengtao Zhu, Peng Li, Shutian Zhang in Cancer Cell International (2019)

Article

Cytoplasmic Asporin promotes cell migration by regulating TGF-β/Smad2/3 pathway and indicates a poor prognosis in colorectal cancer

Previous studies revealed that Asporin (ASPN) is a potential mediator in the development of various types of cancer as a secreted stroma protein, but the function of ASPN inside the cancer cells remains largel...

Hengcun Li, Zheng Zhang, Lei Chen, **u**g Sun, Yu Zhao… in Cell Death & Disease (2019)

Article

Helicobacter pylori infection and inflammatory bowel disease: a crosstalk between upper and lower digestive tract

Helicobacter pylori has coexisted with humans for approximately 60,000 years and greater than 50% of the global population is infected with H. pylori. H. pylori was successfully cultured in vitro in 1983 and stud...

Yang Yu, Shengtao Zhu, Peng Li, Li Min, Shutian Zhang in Cell Death & Disease (2018)

Article

Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries

Ethyl pyruvate (EP) is a simple derivative of pyruvic acid, which is an important endogenous metabolite that can scavenge reactive oxygen species (ROS). Treatment with EP is able to ameliorate systemic inflamm...

Runkuan Yang, Shengtao Zhu, Tor Inge Tonnessen in Journal of Inflammation (2016)

Article

HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity

Acetaminophen (APAP) hepatotoxicity is associated with a high rate of gram-negative enteric bacterial infection; however, the underlying mechanism is still unknown. APAP overdose induces massive hepatocyte nec...

Runkuan Yang, ** Zou, Jyrki Tenhunen, Shengtao Zhu… in BMC Gastroenterology (2014)

Article

High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity

Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect...

Runkuan Yang, Shutian Zhang, Antonella Cotoia, Niku Oksala… in BMC Gastroenterology (2012)

Article

Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity

Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G₀), the regeneration...

Runkuan Yang, Shutian Zhang, Henri Kajander, Shengtao Zhu… in BMC Gastroenterology (2011)