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Article
Ring-substituted analogs of 3,3′-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and –independent prostate cancer cells
We recently reported that novel ring-substituted analogs of 3,3′-diindolylmethane (ring-DIMs) have anti-androgenic and growth inhibitory effects in androgen-dependent prostate cancer cells. The objectives of t...
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Article
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
HOTAIR is a long intervening non-coding RNA (lincRNA) that associates with the Polycomb Repressive Complex 2 (PRC2) and overexpression is correlated with poor survival for breast, colon and liver cancer patien...
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Article
Erratum: The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53
Correction to: Oncogene (2012) 31, 3265–3276; doi:10.1038/onc.2011.504; published online 14 November 2011 Since the publication of the above manuscript the authors have identified an error in the author list; ...
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Article
The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53
The orphan nuclear receptor TR3 (NR41A and Nur77) is overexpressed in most lung cancer patients and is a negative prognostic factor for patient survival. The function of TR3 was investigated in non-small-cell ...
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Article
Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
The human POK family members are transcription factors with a POZ domain and zinc-fingers that act primarily as transcriptional repressors. Several members of this family are involved in oncogenesis and this p...
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Article
Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells
Purpose: 1,3,6,8-Substituted alkyl polychlorinated dibenzofurans (PCDFs), typified by 6-methyl-1,3,8-triCDF (MCDF), inhibit 17β-estradiol (E2)-induced responses in the rodent uterus and human breast cancer cells...
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Article
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells
Hs578T human breast cancer cells are an oestrogen receptor (ER)-negative cell line. Treatment of these cells with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in formation of a 6.9 S nuclear aryl hydroc...
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Article
Effects of individual terphenyls and polychlorinated terphenyls on rat hepatic microsomal cytochrome P-450-dependent monooxygenases: structure-activity relationships
The effects of o-, m- and p-terphenyl, 2,4-dichloro-, 2,4,6-trichloro-, 2,3,5,6-tetrachloro-, 2,3,4,6-tetrachloro-, 2,4,4'",6- tetrachloro- and 2,3,4,5-tetrachloro-p-terphenyl, 2,3,4,5-tetrachloro-m- and o-terphe...
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Article
Identification of toxic impurities in commercial Diphenylamine
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Article
Uptake and distribution of chloronaphthalenes and their metabolites in pigs
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Article
Metabolism of 4-chlorobiphenyl by lichens
Eighteen lichens from a variety of habitats were treated with 4-chlorobiphenyl (4-CB). All, as determined by means of radioactive tracers, were shown to partially convert 4-CB to 4-chloro-4′-hydroxybiphenyl. O...
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Article
Identification of metabolic dechlorination of highly chlorinated biphenyl in rabbit
CHLOROBIPHENYLS with one to four chlorine atoms per molecule are metabolised by certain animals, plants and microorganisms but the more highly chlorinated biphenyls are rather resistant to metabolic change1.
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Article
Lipid and alkali extractable fatty acids fromMucor rouxii: Effect of thermal changes in growth environment and age of cells
The lipid levels of the fungusMucor rouxii are affected markedly by both the growth temperature and the age of the cells. Both chloroform-methanol extractable (fraction I) and alkali extractable (fraction II) fat...
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Article
Detection of the ergosterol and episterol isomers lichesterol and fecosterol in nystatin-resistant mutants of Neurospora crassa
Wild-type Neurospora crassa is completely inhibited by 5 ppm nystatin. Ultraviolet-induced mutants have been isolated that grow in the presence of 60 ppm of the antibiotic. Gas-liquid chromatographic, mass spectr...
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Article
Identification of 4-chloro-4′-hydroxybiphenyl and 4,4′-dichloro-3-hydroxybiphenyl as metabolites of 4-chloro- and 4,4′-dichlorobiphenyl fed to rats
Identifizierung und Strukturaufklärung zweier Metaboliten von 4-Chorbiphenyl und 4,4′-Dichlorbiphenyl mittels NMR-Spektroskopie.
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Article
Effect of oxygen levels on the fatty acids and lipids ofMucor rouxii
The effect of aerobic and oxygen limiting (anaerobic) growth conditions upon the fatty acid and lipid composition ofMucor rouxii has been examined. The aerobic cells contained a range of fatty acids typical of ph...
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Article
Lipid composition ofChaetomium cochliodes: Effect of media
The fatty acid and lipid compositions ofChaetomium cochliodes grown on three different media are compared. Although the growth media effects dramatic changes in the antibiotic production, only minor alterations i...
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Article
7-Methyl-7-hexadecenoic acid: Isolation from lipids of the ocean sunfishMola mola (Linnaeus) 1758
A fatty acid amounting to several per cent of the acids in various samples of the liver oil of the ocean sunfishMola mola was isolated and characterized as 7-methyl-7-hexadecenoic acid. This acid and the previous...
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Article
A general method for the preparation of tritiated polychlorobiphenyls of high specific activity: 2,2′,5,5′-tetrachlorobiphenyl-[3H] and 2,2′,4,4′,5,5′-hexachlorobiphenyl-[3H]
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Article
Polychlorinated Biphenyls: Photolysis of 2,4,6,2′,4′,6′-Hexachlorobiphenyl
MANY aromatic organochlorine compounds are readily utilized or otherwise decomposed by a number of specific microorganisms. In the environment, however, these compounds are relatively stable and resistant to g...
