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Article
Open AccessAMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...
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Article
Open AccessMulti-agent system-based polymorphic distributed energy management for ships entering and leaving ports considering computing power resources
In order to realize the intelligent energy management of the complex ship energy system, achieve the carbon peaking and carbon neutrality goal and reduce the ship carbon emissions and ship operating costs, thi...
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Article
Open AccessFunctional investigation of SLC1A2 variants associated with epilepsy
Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing excitotoxicity via clear...
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Article
Open AccessThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not ...
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Article
Open AccessLow-dose metformin targets the lysosomal AMPK pathway through PEN2
Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects1–4. For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role ...
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Article
Open AccessSource-Adaptation-Based Wireless Video Transport: A Cross-Layer Approach
Real-time packet video transmission over wireless networks is expected to experience bursty packet losses that can cause substantial degradation to the transmitted video quality. In wireless networks, channel ...
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Article
Open AccessCross-Layer QoS Control for Video Communications over Wireless Ad Hoc Networks
Assuming a wireless ad hoc network consisting of homogeneous video users with each of them also serving as a possible relay node for other users...