4 Result(s)

Article

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...

Mengqi Li, Yu Wang, **aoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu… in Cell Research (2024)

Article

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not ...

Chen-Song Zhang, Mengqi Li, Yu Wang, **aoyang Li, Yue Zong… in Nature Metabolism (2022)

Article

PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron

**gyi Su, **g Zheng, Wei Huang, Yali Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects^1–4. For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role ...

Teng Ma, **ao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu… in Nature (2022)