1,009 Result(s)

Article

Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue, Zhenhua Feng, Putao Yuan, Li Qiao, Qiliang Lou… in Cell Death Discovery (2024)

Article

Correction: Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Xuexia Zhou, Xuebing Li, Run Wang, Dan Hua, Cuiyun Sun, Lin Yu… in Cell Death & Disease (2024)

Article

Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice

Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive. Protein kinase C-delta (PKC-δ) plays critical roles in the co...

Dongyun Wang, Yue Li, Guiying Li, Mengyu Liu, Zihui Zhou, Ming Wu… in Cell Death Discovery (2024)

Article

Phase separation of RNF214 promotes the progression of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been obse...

Zheng-Jie He, Ke He, Song-Wang Cai, Rui Zhang, Zhong-Bao Shao… in Cell Death & Disease (2024)

Article

S100A8/A9^hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis

S100a8/a9, largely released by polymorphonuclear neutrophils (PMNs), belongs to the S100 family of calcium-binding proteins and plays a role in a variety of inflammatory diseases. Although S100a8/a9 has been r...

Yanghanzhao Wang, Yuxin Shi, Yuwen Shao, **hua Lu, Hao Zhang… in Cell Death & Disease (2024)

Article

TNIP3 protects against pathological cardiac hypertrophy by stabilizing STAT1

Pathological cardiac hypertrophy is one of the major risk factors of heart failure and other cardiovascular diseases. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown....

Hongjie Shi, Yongjie Yu, Dajun Li, Kun Zhu, Xu Cheng, Tengfei Ma… in Cell Death & Disease (2024)

Article

CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia

Peripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been reported to exert pyroptosis and play a critical role in the pat...

Yiwen Wang, Yang Gao, Huairui Shi, Rifeng Gao, Ji’e Yang, Ya’nan Qu… in Cell Death Discovery (2024)

Article

Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response

Non-small cell lung cancer (NSCLC) presents a global health challenge due to its low five-year survival rates, underscoring the need for novel therapeutic strategies. Our research explored the synergistic mech...

Yiman Li, Yan Song, Zhi**g Shi, Huijie Hou, Yang Yu, Fei Pan… in Cell Death & Disease (2024)

Article

The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth

Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain larg...

Chenrui Wang, Song Cao, Chen Shi, Mengbo Guo… in Cellular and Molecular Life Sciences (2024)

Article

Prostaglandin I₂ signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice

Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I₂ (PGI₂) can prevent the process of fibrosis in various tissue...

Yue Zhang, Meng Yuan, Wenbin Cai, Weiyan Sun… in Cellular and Molecular Life Sciences (2024)

Article

EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease

Peroxisomal l-bifunctional enzyme (EHHADH) plays a role in the classic peroxisomal fatty acid β-oxidation pathway; however, the relationship between EHHADH expression and diabetic kidney disease has not been well...

Shuyan Kan, Qing Hou, **song Shi, Mingchao Zhang, Feng Xu… in Cell Death Discovery (2024)

Article

ZFHX3 acts as a tumor suppressor in prostate cancer by targeting FTO-mediated m⁶A demethylation

Zinc-finger homeobox 3 (ZFHX3, also known as ATBF1) suppresses prostatic tumorigenesis. ZFHX3 is frequently found to have numerous deletions in human prostate cancer (PCa). However, the underlying molecular fu...

Qingxia Hu, Junling Yin, Sijie Zhao, Yibo Wang, Ruxue Shi… in Cell Death Discovery (2024)

Article

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose deprivation. However, the specific regulatory mechanism remains large...

Miaomiao Li, Wen**g Huang, Yuan Zhang, Yue Du, Shan Zhao… in Cell Death & Disease (2024)

Article

Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway

Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms that underlie this phenomenon have yet to be extensively investigated. The Morris w...

Hongxia Li, Wenlan Pan, Chenqi Li, Mengyu Cai, Wen**g Shi… in Cell Death Discovery (2024)

Article

Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling

Acute liver failure (ALF) is a disease with a high mortality rate and poor prognosis, whose pathogenesis is not fully understood. PANoptosis is a recently proposed mode of cell death characterized by pyroptosi...

Chunxia Shi, Yukun Wang, ** Guo, Danmei Zhang, Yanqiong Zhang… in Cell Death Discovery (2024)

Article

HOXD10 attenuates renal fibrosis by inhibiting NOX4-induced ferroptosis

In chronic kidney disease (CKD), renal fibrosis is an unavoidable result of various manifestations. However, its pathogenesis is not yet fully understood. Here, we revealed the novel role of Homeobox D10 (HOXD...

**n Li, Tian-Kui Ma, Pu Wang, Hang Shi, Sang Hai, Yu Qin, Yun Zou… in Cell Death & Disease (2024)