5 Result(s)
within
Guillermo Pérez-Hernández
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Article
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by promoting guanine nucleotide exchange. Here, we investigate the coupling of G proteins with GPCRs and describe the events that ultimate...
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Article
Time-resolved cryo-EM of G-protein activation by a GPCR
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating guanine nucleotide exchange in the Gα subunit1. To visualize this mechanism, we developed a time-resolved cryo-EM approach tha...
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Article
Open AccessFunction and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor
Advances in structural biology have provided important mechanistic insights into signaling by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is known about intrinsically diso...
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Article
Open AccessDefining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance
The rise of multi-drug resistance in bacterial pathogens is one of the grand challenges facing medical science. A major concern is the speed of development of β-lactamase-mediated resistance in Gram-negative spec...
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Article
Singlet oxygen generation versus O–O homolysis in phenyl-substituted anthracene endoperoxides investigated by RASPT2, CASPT2, CC2, and TD-DFT methods
The electronic excited states corresponding to singlet oxygen generation versus O–O splitting in o-fluorine-phenyl-9-anthracene-9,10-endoperoxide 1 and its 9,10-bisarylanthracene analog 2 have been investigated u...
