73 Result(s)

Article

Combined positive/negative selection for highly effective purging of PBPC grafts: towards clinical application in patients with B-CLL

Autologous PBPC transplantation is a potentially curative treatment for patients with chronic lymphocytic leukemia (CLL). As the autografts are frequently contaminated with large numbers of tumor cells, we hav...

U Paulus, N Schmitz, K Viehmann, N von Neuhoff, P Dreger in Bone Marrow Transplantation (1997)

Article

Allogeneic peripheral blood progenitor cells for treatment of relapse after bone marrow transplantation

Donor leukocyte infusions (DLI) are an effective therapy for patients who relapse with leukemia after bone marrow transplantation (BMT). Severe graft-versus-host disease and prolonged periods of pancytopenia c...

B Glass, I Majolino, P Dreger, R Scimè, A Santoro, S Vasta… in Bone Marrow Transplantation (1997)

Article

Long-term disease-free survival of patients with advanced mantle-cell lymphoma following high-dose chemotherapy

In advanced stage mantle cell lymphoma, conventional chemotherapy yields a complete remission rate below 40%, and the median survival rate is only about 3 years. Between 1991 and 1996 we treated nine such pati...

N Kröger, M Hoffknecht, P Dreger, W Krüger, W Zeller… in Bone Marrow Transplantation (1998)

Article

Comparison of different strategies of molecular genetic monitoring following autologous stem cell transplantation in patients with follicular lymphoma

Two different molecular genetic methods were compared for their suitability for monitoring minimal residual disease in patients with follicular lymphoma (FL) treated with high-dose therapy and autologous stem ...

N von Neuhoff, P Dreger, M Suttorp, M Marget, S Kell… in Bone Marrow Transplantation (1998)

Article

Autografting of highly purified peripheral blood progenitor cells following myeloablative therapy in patients with lymphoma: a prospective study of the long-term effects on tumor eradication, reconstitution of hematopoiesis and immune recovery

In a prospective study, we have investigated CD34⁺ selection of peripheral blood progenitor cells (PBPC) for autotransplantation in patients with lymphoma. Twenty-six consecutive patients (10 follicular lymphomas...

P Dreger, K Viehmann, N von Neuhoff, T Glaubitz, O Petzoldt… in Bone Marrow Transplantation (1999)

Article

Hepatitis B viremia in a patient with documented previous HBV immunity after autologous transplantation of highly purified PBSC

P Dreger, P Rautenberg, M Kneba, N Schmitz in Bone Marrow Transplantation (2000)

Article

Reduced-intensity allogeneic stem cell transplantation as salvage treatment for patients with indolent lymphoma or CLL after failure of autologous SCT

P Dreger, B Glass, B Seyfarth, A Humpe, A Claviez… in Bone Marrow Transplantation (2000)

Article

Elevated blood drug levels obtained from indwelling silicon catheters during oral cyclosporine A administration

Cyclosporine A (CsA) may be bound to and released from the inner surface of central venous catheters resulting in spuriously elevated blood drug levels. We observed this phenomenon in a boy transplanted becaus...

A Claviez, B Glass, P Dreger, M Suttorp in Bone Marrow Transplantation (2002)

Article

Autologous and allogeneic stem cell transplantation for chronic lymphocytic leukemia

Allogeneic and autologous stem cell transplantation (SCT) are increasingly considered for treatment of patients with chronic lymphocytic leukemia (CLL). In order to assess the potential therapeutic value of SC...

P Dreger, E Montserrat in Leukemia (2002)

Article

Chronische lymphatische Leukämie Aktuelle Therapiekonzepte

Die chronische lymphatische Leukämie (CLL) ist die häufigste Leukämie der westlichen Welt. In den letzten 10 Jahren haben sich die Konzepte zur Therapie der CLL erheblich geändert. Neue Therapieverfahren wie P...

M. Hallek, M. Bergmann, G. Brittinger, H. Döhner, P. Dreger, M. Herold… in Der Internist (2002)

Article

Treatment-related mortality and graft-versus-leukemia activity after allogeneic stem cell transplantation for chronic lymphocytic leukemia using intensity-reduced conditioning

Allogeneic stem cell transplantation (SCT) using reduced-intensity conditioning (RIC) has potential to be a promising treatment of aggressive chronic lymphocytic leukemia (CLL). Since available clinical data o...

P Dreger, R Brand, J Hansz, D Milligan, P Corradini, J Finke, G L Deliliers… in Leukemia (2003)

Article

Enhanced antileukemic activity of allogeneic peripheral blood progenitor cell transplants following donor treatment with the combination of granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) in a murine transplantation model

Allogeneic peripheral blood progenitor cells (PBPCs) have mostly been mobilized by granulocyte colony-stimulating factor (G-CSF). There is neither clinical nor experimental data available addressing the questi...

G Hartung, M Zeis, B Glass, P Dreger, J Steinmann, N Schmitz… in Bone Marrow Transplantation (2003)

Article

Reduced-intensity conditioning prior to allogeneic transplantation of hematopoietic stem cells: the need for T cells early after transplantation to induce a graft-versus-lymphoma effect

In patients with poor-risk relapse of aggressive lymphoma, reduced-intensity conditioning followed by allogeneic PBSCT may have its limitations because of rapid regrowth of the tumor. We tried to address this ...

B Glass, M Nickelsen, P Dreger, A Claviez, J Hasenkamp… in Bone Marrow Transplantation (2004)

Article

Comparative analysis of minimal residual disease detection using four-color flow cytometry, consensus IgH-PCR, and quantitative IgH PCR in CLL after allogeneic and autologous stem cell transplantation

The clinically most suitable method for minimal residual disease (MRD) detection in chronic lymphocytic leukemia is still controversial. We prospectively compared MRD assessment in 158 blood samples of 74 pati...

S Böttcher, M Ritgen, C Pott, M Brüggemann, T Raff, S Stilgenbauer, H Döhner… in Leukemia (2004)

Article

Identification of a survivin-derived peptide that induces HLA-A*0201-restricted antileukemia cytotoxic T lymphocytes

S Siegel, J Steinmann, N Schmitz, R Stuhlmann, P Dreger, M Zeis in Leukemia (2004)

Article

Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: a population-matched analysis

To elucidate whether reduced-intensity conditioning (RIC) decreases treatment-related mortality (TRM) after allogeneic stem cell transplantation (allo-SCT) for chronic lymphocytic leukemia (CLL), we retrospect...

P Dreger, R Brand, D Milligan, P Corradini, J Finke, G Lambertenghi Deliliers… in Leukemia (2005)

Article

Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus

The aim of this project was to identify situations where allogeneic stem cell transplantation (allo-SCT) might be considered as a preferred treatment option for patients with B-cell chronic lymphocytic leukemi...

P Dreger, P Corradini, E Kimby, M Michallet, D Milligan, J Schetelig… in Leukemia (2007)

Article

Quantitative MRD monitoring identifies distinct GVL response patterns after allogeneic stem cell transplantation for chronic lymphocytic leukemia: results from the GCLLSG CLL3X trial

The purpose of this study was to prospectively analyze minimal residual disease(MRD) kinetics after reduced-intensity allogeneic stem cell transplantation (allo-SCT) in high-risk chronic lymphocytic leukemia (...

M Ritgen, S Böttcher, S Stilgenbauer, D Bunjes, J Schubert, S Cohen, A Humpe… in Leukemia (2008)

Article

Occurrence of donor-derived CLL 8 years after sibling donor SCT for CML

J B Perz, M Ritgen, M Moos, A D Ho, M Kneba, P Dreger in Bone Marrow Transplantation (2008)