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  1. No Access

    Article

    The Heptapeptide SEMAX stimulates BDNF Expression in Different Areas of the Rat Brain in vivo

    O. V. Dolotov, T. S. Seredenina, N. G. Levitskaya… in Doklady Biological Sciences (2003)

  2. No Access

    Article

    The Binding of Semax, ACTH 4–10 Heptapeptide, to Plasma Membranes of the Rat Forebrain Basal Nuclei and Its Biodegradation

    The binding characteristics of the peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) to plasma membranes of basal nuclei of the rat forebrain and the dynamics of its degradation during its incubation with these memb...

    O. V. Dolotov, Yu. A. Zolotarev, E. M. Dorokhova… in Russian Journal of Bioorganic Chemistry (2004)

  3. No Access

    Article

    Different Effects of Enhanced and Reduced Expression of pub Gene on the Formation of Embryoid Bodies by Cultured Embryonic Mouse Stem Cell

    The effects of pub gene on proliferation and initial stages of differentiation of embryonic mouse stem cells were studied in vitro. To this end we used enhanced expression of human pub gene (hpub) and suppression...

    E. V. Novosadova, E. S. Manuilova… in Bulletin of Experimental Biology and Medic… (2005)

  4. No Access

    Article

    Evenly tritium labeled peptides in study of peptide in vivo and in vitro biodegradation

    Biologically active peptides evenly labeled with tritium were used for studying the in vitro and in vivo biodegradation of the peptides. Tritium-labeled peptides with a specific radioactivity of 50–150 Ci/mmol...

    Yu. A. Zolotarev, A. K. Dadayan, O. V. Dolotov… in Russian Journal of Bioorganic Chemistry (2006)

  5. No Access

    Article

    Degradation of the ACTH(4-10) analog Semax in the presence of rat basal forebrain cell cultures and plasma membranes

    Here a new approach of the elucidation of paths of proteolytic biodegradation of physiologically active peptides, based on the use of a peptide with isotopic label at all amino acid residues and the enrichment...

    Yu. A. Zolotarev, O. V. Dolotov, L. S. Inozemtseva, A. K. Dadayan… in Amino Acids (2006)

  6. No Access

    Article

    Study of auto- and heteroreceptor components of the presynaptic dopamine reuptake modulation in the mechanism of the in vitro action of the novel antiparkinsonian drug hemantane

    The effect of Hemantane, a new 2-aminoadamantane derivative (N-adamant-2-ylhexamethylenimine hydrochloride) with antiparkinsonian activity on [3H]-dopamine ([3H]-DA) uptake and binding by D1, D2, and D3 dopamine ...

    G. I. Kovalev, D. A. Abaimov, M. V. Voronin, J. Yu. Firstova… in Neurochemical Journal (2007)

  7. No Access

    Article

    Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo

    L. S. Inozemtseva, E. A. Karpenko, O. V. Dolotov… in Doklady Biological Sciences (2008)

  8. No Access

    Article

    The CREB transcription factor and processes of memory formation

    The CREB protein (cyclic AMP response element-binding protein) is a well studied and important transcription factor. Current experimental data suggest that CREB-dependent gene expression plays a critical role ...

    E. V. Dubynina, O. V. Dolotov in Neurochemical Journal (2009)

  9. No Access

    Article

    Alpha-melanocyte-stimulating hormone increases the expression of vascular endothelial growth factor in rat hippocampal astrocytes in vitro

    Alpha-melanocyte-stimulating hormone (α-MSH) is a regulator of many physiological processes that has neuroprotective characteristics. In this work, we showed the expression of the melanocortin receptor MC4R in...

    E. V. Dubynina, L. S. Inozemtseva, D. D. Markov, K. A. Yatsenko… in Neurochemical Journal (2009)

  10. No Access

    Article

    Neurotropic activity of ACTH7–10PGP, an analog of an ACTH fragment

    N. Yu. Glazova, M. S. Atanov, A. V. Pyzgareva… in Doklady Biological Sciences (2011)

  11. No Access

    Article

    Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats

    K. A. Yatsenko, N. Yu. Glazova, L. S. Inozemtseva… in Doklady Biological Sciences (2013)

  12. No Access

    Article

    Semax prevents the death of tyrosine hydroxylase-positive neurons in a mixed neuroglial cell culture derived from the embryonic rat mesencephalon in a model of 6-hydroxydopamine-induced neurotoxicity

    The peptide Semax (MEHFPGP), which is an analogue of the ACTH (4–10) fragment, has a wide spectrum of activity in the nervous system of mammals, including humans. Using a model of neurotoxicity induced by hydr...

    O. V. Dolotov, K. O. Eremin, L. A. Andreeva, E. V. Novosadova… in Neurochemical Journal (2015)

  13. No Access

    Article

    Effect of Nerve Growth Factor on Neural Differentiation of Mouse Embryonic Stem Cells

    The cholinergic, GABAergic, and catecholaminergic neurons derived from mouse embryonic stem cells in a culture medium supplemented with recombinant NGF were phenotyped and scored. NGF stimulated generation of ...

    S. A. Antonov, E. S. Manuilova… in Bulletin of Experimental Biology and Medic… (2017)

  14. No Access

    Article

    Long-Term Changes in Behavior and the Content of BDNF in the Rat Brain Caused by Neonatal Isolation: The Effects of an Analog of ACTH(4-10) Semax

    Exposure to stress during early postnatal development can cause neurological disorders in adulthood. The aim of this study was to evaluate changes in behavior, learning ability, and the content of the neurotro...

    Yu. A. Sukhanova, M. A. Volodina, E. A. Sebentsova, N. Yu. Glazova… in Neurochemical Journal (2018)

  15. No Access

    Article

    Parkinson’s Disease–Associated Changes in the Expression of Neurotrophic Factors and their Receptors upon Neuronal Differentiation of Human Induced Pluripotent Stem Cells

    Parkinson’s disease (PD) is a neurodegenerative pathology resulting from the degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Neurotrophic factors (NTFs) and their receptors are key regu...

    E. V. Novosadova, V. V. Nenasheva, I. V. Makarova… in Journal of Molecular Neuroscience (2020)

  16. No Access

    Article

    Effects of Fragment ACTH15-18 and Its Analog ACTH15-18Pro-Gly-Pro on the Sequelae of Acute Stress

    Tetrapeptide KKRR, corresponding to the ACTH15-18 sequence, is the shortest fragment with high-affinity binding with the ACTH receptor; it does not activate this receptor and prevents the whole hormone molecule f...

    D. M. Manchenko, N. Yu. Glazova, E. A. Sebentsova… in Neuroscience and Behavioral Physiology (2023)

  17. No Access

    Article

    Directed Neuronal Differentiation of SH-SY5Y Human Neuroblastoma Cells on 2D Matrices Containing Recombinant Spidroins Modified with Cell Adhesion Peptides

    The use of efficient and inexpensive substrates (2D matrices) for cultivation and differentiation of nerve cells in vitro is important for the creation of tissue engineering constructs intended for the treatme...

    O. D. Kurko, L. I. Davydova, K.V. Sidoruk… in Molecular Genetics, Microbiology and Virol… (2023)