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Open AccessValidation of the IOF quality of life questionnaire for patients with wrist fracture
Wrist fracture causes pain and decreased physical, social and emotional function. The International Osteoporosis Foundation has developed a specific questionnaire to assess quality of life in patients with wri...
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Article
BMD, clinical risk factors and their combination for hip fracture prevention
This study examined the effects of the use of clinical risk factors (CRFs) alone, BMD alone or the combination using the FRAX® tool for the detection of women at risk of hip fracture. BMD tests alone selected ...
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Open AccessFRAX™ and the assessment of fracture probability in men and women from the UK
A fracture risk assessment tool (FRAX™) is developed based on the use of clinical risk factors with or without bone mineral density tests applied to the UK.
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Article
Cost-effectiveness of alendronate in the treatment of postmenopausal women in 9 European countries - an economic evaluation based on the fracture intervention trial
Treatment with alendronate (Fosamax®) has been shown to significantly reduce the risk of fragility fractures. Cost-effectiveness of treatment was assessed in nine European countries in a Markov model and was g...
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Article
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone.
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Latitude, socioeconomic prosperity, mobile phones and hip fracture risk
Epidemiological observations suggest that sunlight exposure is an important determinant of hip fracture risk. The aim of this ecological study was to examine the relationship between latitude and hip fracture ...
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An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
The aim of this study was to quantify the global burden of osteoporotic fracture worldwide.
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Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women
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At what hip fracture risk is it cost-effective to treat?
Intervention thresholds (ITs), the 10-year hip fracture risk at which treatment can be considered to be cost-effective, have previously been estimated for Sweden and the UK.
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Article
Whom to treat? The contribution of vertebral X-rays to risk-based algorithms for fracture prediction. Results from the European Prospective Osteoporosis Study
Vertebral fracture is a strong risk factor for future spine and hip fractures; yet recent data suggest that only 5–20% of subjects with a spine fracture are identified in primary care. We aimed to develop easi...
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Article
The cost-effectiveness of risedronate in the treatment of osteoporosis: an international perspective
Risedronate, a bisphosphonate for treatment and prevention of osteoporosis, has been shown in several clinical trials to reduce the risk of fractures in postmenopausal women with osteoporosis. The cost-effecti...
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Article
Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women
The incidence of fragility fractures begins to increase in middle age. We investigated prospectively risk factors for low-energy fractures in men and women, and specifically for forearm, proximal humerus, vert...
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Article
The use of multiple sites for the diagnosis of osteoporosis
It has been suggested that bone mineral density (BMD) measurements should be made at multiple sites, and that the lowest T–score should be taken for the purpose of diagnosing osteoporosis.
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Development of the Qualeffo–31, an osteoporosis-specific quality-of-life questionnaire
Vertebral deformities are a common consequence of osteoporosis and are known to decrease quality of life. The Qualeffo–41 is a quality-of-life questionnaire especially developed for measuring quality of life i...
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Article
Daily Physical Education in the School Curriculum in Prepubertal Girls during 1 Year is Followed by an Increase in Bone Mineral Accrual and Bone Width—Data from the Prospective Controlled Malmö Pediatric Osteoporosis Prevention Study
The aim of this study was to evaluate a general school-based 1-year exercise intervention program in a population-based cohort of girls at Tanner stage I. Fifty-three girls aged 7–9 years were included. The sc...
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Economic evaluation of parathyroid hormone (PTH) in the treatment of osteoporosis in postmenopausal women
Parathyroid hormone (PTH) is a new treatment for osteoporosis and has been shown to reduce the risks of vertebral and non-vertebral fractures in postmenopausal women in clinical trials. The objective of this s...
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Body mass index as a predictor of fracture risk: A meta-analysis
Low body mass index (BMI) is a well-documented risk factor for future fracture. The aim of this study was to quantify this effect and to explore the association of BMI with fracture risk in relation to age, ge...
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Ten-year probabilities of clinical vertebral fractures according to phalangeal quantitative ultrasonography
The objectives of the present study were to estimate 10-year probabilities of clinical vertebral fractures in women, according to age and bone mineral assessment using phalangeal quantitative ultrasound (QUS)....
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Article
Risedronate decreases fracture risk in patients selected solely on the basis of prior vertebral fracture
The aim of this study was to examine the effects of risedronate (5 mg/daily) in patients identified solely on the basis of a prior fragility fracture, without BMD as an inclusion criterion. A total of 1,802 pa...
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Long-Term Morbidity and Mortality After a Clinically Diagnosed Vertebral Fracture in the Elderly—a 12- and 22-Year Follow-up of 257 Patients
The objective of this study was to analyze the long-term morbidity and mortality in patients with a clinically diagnosed vertebral fracture. Seventy men with a mean age of 70 years (range 50–91 years) and 187 ...