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Article
Characteristics of recurrent fractures
The present study, drawn from a sample of the Icelandic population, quantified high immediate risk and utility loss of subsequent fracture after a sentinel fracture (at the hip, spine, distal forearm and humer...
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Article
Low risk for hip fracture and high risk for hip arthroplasty due to osteoarthritis among Swedish farmers
We aimed to study the risk of hip fracture and risk of hip arthroplasty among farmers in Sweden. Our results indicate that farming, representing an occupation with high physical activity, in men is associated ...
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Article
Imminent risk of fracture after fracture
The risk of major osteoporotic fracture (MOF) after a first MOF is increased over the whole duration of follow-up, but the imminent risk is even higher. If the acute increment in risk in the few years followin...
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Article
Open AccessIncreased risk of hip fracture among spouses—evidence of a homogamy effect
Spouses tend to share habits and therefore have an increased risk of same diseases. We followed all married couples in Sweden, born 1902 to 1942, in hospital records from 1987 to 2002, and found that individua...
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Article
Open AccessBody fat mass and the proportion of very large adipocytes in pregnant women are associated with gestational insulin resistance
Pregnancy is accompanied by fat gain and insulin resistance. Changes in adipose tissue morphology and function during pregnancy and factors contributing to gestational insulin resistance are incompletely known...
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Article
FRAX predicts incident falls in elderly men: findings from MrOs Sweden
Falls and fractures share several common risk factors. Although past falls is not included as an input variable in the FRAX calculator, we demonstrate that FRAX probability predicts risk of incident falls in t...
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Article
FRAX and the effect of teriparatide on vertebral and non-vertebral fracture
Daily teriparatide injections have been shown to reduce vertebral and non-vertebral fractures. Here, we demonstrate that the magnitude of fracture risk reduction is independent of baseline fracture probability...
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Article
Is the Swedish FRAX model appropriate for Swedish immigrants?
The incidence of hip fracture in Sweden is substantially lower in immigrants than in the population born in Sweden. Thus, the use of a FRAX® model in immigrants overestimates the risk of fracture, and the use ...
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Article
Burden of high fracture probability worldwide: secular increases 2010–2040
The number of individuals aged 50 years or more at high risk of osteoporotic fracture worldwide in 2010 was estimated at 158 million and is set to double by 2040.
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Article
Open AccessEfficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX
The aim of this study was to determine the efficacy of once-weekly teriparatide as a function of baseline fracture risk. Treatment with once-weekly teriparatide was associated with a statistically significant ...
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Article
FRAX-based assessment and intervention thresholds—an exploration of thresholds in women aged 50 years and older in the UK
Under current guidelines, based on prior fracture probability thresholds, inequalities in access to therapy arise especially at older ages (≥70 years) depending on the presence or absence of a prior fracture. ...
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Article
Predictive ability of heel quantitative ultrasound for incident fractures: an individual-level meta-analysis
The relationship between bone quantitative ultrasound (QUS) and fracture risk was estimated in an individual level data meta-analysis of 9 prospective studies of 46,124 individuals and 3018 incident fractures....
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Article
Impact of Femoral Neck and Lumbar Spine BMD Discordances on FRAX Probabilities in Women: A Meta-analysis of International Cohorts
There are occasional marked discordances in BMD T-scores at the lumbar spine (LS) and femoral neck (FN). We investigated whether such discordances could contribute independently to fracture prediction using F...
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Article
Waning predictive value of serum adiponectin for fracture risk in elderly men: MrOS Sweden
Serum adiponectin is a risk factor for fracture. The predictive value attenuates with time in elderly men so that its use for the risk assessment in the long term is questionable. The study underlines the impo...
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Article
Mild morphometric vertebral fractures predict vertebral fractures but not non-vertebral fractures
In this meta-analysis of the control arms of four phase 3 trials, mild vertebral fractures were a significant risk factor for future vertebral fractures but not for non-vertebral fracture.
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Article
Variations in latitude may or may not explain the worldwide variation in hip fracture incidence
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Article
Open AccessA systematic review of hip fracture incidence and probability of fracture worldwide
The country-specific risk of hip fracture and the 10-year probability of a major osteoporotic fracture were determined on a worldwide basis from a systematic review of literature. There was a greater than 10-f...
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Article
Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden
In elderly man, low serum 25-hydroxyvitamin D (25(OH)D) was associated with a substantial excess risk of death compared to 25(OH)D values greater than 50–70 nmol/l, but the association attenuated with time.
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Article
High serum total cholesterol is a long-term cause of osteoporotic fracture
Risk factors for osteoporotic fractures were evaluated in 1,396 men and women for a period of 20 years. Serum total cholesterol was found to be an independent osteoporotic fracture risk factor whose predictive...
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Article
Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden
We studied the nature of the relationship between bone mineral density (BMD) and the risk of death among elderly men. BMD was associated with mortality risk and was independent of adjustments for other co-morb...
