25 Result(s)

Article

Vertebral Scheuermann’s disease in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over

In 27 centres across Europe, the prevalence of deforming spinal Scheuermann’s disease in age-stratified population-based samples of over 10,000 men and women aged 50+ averaged 8 % in each sex, but was highly v...

G. Armbrecht, D. Felsenberg, M. Ganswindt, M. Lunt… in Osteoporosis International (2015)

Article

Enrichment of vitamin D response elements in RA-associated loci supports a role for vitamin D in the pathogenesis of RA

The aim of this study was to explore the role of vitamin D in rheumatoid arthritis (RA) pathogenesis by investigating the enrichment of vitamin D response elements (VDREs) in confirmed RA susceptibility loci a...

A Yarwood, P Martin, J Bowes, M Lunt, J Worthington, A Barton, S Eyre in Genes & Immunity (2013)

Article

MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms

Association of two key variants map** to the MTHFR gene (C677T (rs1801133) and A1298C (rs1801131)) with response to methotrexate (MTX) remains controversial. We investigated these and other markers spanning the...

S A Owen, M Lunt, J Bowes, S L Hider, I N Bruce, W Thomson… in The Pharmacogenomics Journal (2013)

Article

Impact of prevalent and incident vertebral fractures on utility: results from a patient-based and a population-based sample

Data are scarce on the impact of vertebral fractures (VFX) on utility. The objective of this study was to assess the impact of prevalent and incident VFX on utility in both a patient-based and population-based...

N. M. van Schoor, S. K. Ewing, T. W. O’Neill, M. Lunt… in Quality of Life Research (2008)

Article

Whom to treat? The contribution of vertebral X-rays to risk-based algorithms for fracture prediction. Results from the European Prospective Osteoporosis Study

Vertebral fracture is a strong risk factor for future spine and hip fractures; yet recent data suggest that only 5–20% of subjects with a spine fracture are identified in primary care. We aimed to develop easi...

S. Kaptoge, G. Armbrecht, D. Felsenberg, M. Lunt, K. Weber… in Osteoporosis International (2006)

Article

Back pain, disability, and radiographic vertebral fracture in European women: a prospective study

Vertebral fractures are associated with back pain and disability. There are, however, few prospective data looking at back pain and disability following identification of radiographic vertebral fracture. The a...

T. W. O’Neill, W. Cockerill, C. Matthis, H. H. Raspe, M. Lunt… in Osteoporosis International (2004)

Article

Health-related quality of life and radiographic vertebral fracture

Background: Vertebral fractures are associated with back pain and disability; however, relatively little is known about the impact of radiographic vertebral fractures on quality of life i...

W. Cockerill, M. Lunt, A. J. Silman, C. Cooper, P. Lips… in Osteoporosis International (2004)

Article

Determinants of incident vertebral fracture in men and women: results from the European Prospective Osteoporosis Study (EPOS)

 The aim of this analysis was to determine the influence of lifestyle, anthropometric and reproductive factors on the subsequent risk of incident vertebral fracture in men and women aged 50–79 years. Subjects ...

D.K. Roy, T.W. O'Neill, J.D. Finn, M. Lunt, A.J. Silman… in Osteoporosis International (2003)

Article

Defining Incident Vertebral Deformities in Population Studies: A Comparison of Morphometric Criteria

Various morphometric criteria have been used to define incident vertebral deformity. The aim of this analysis was to compare the relative validity of two established criteria and a novel method in which these...

M. Lunt, A. A. Ismail, D. Felsenberg, C. Cooper, J. A. Kanis… in Osteoporosis International (2002)

Article

Incidence of Limb Fracture across Europe: Results from the European Prospective Osteoporosis Study (EPOS)

The aim of this population-based prospective study was to determine the incidence of limb fracture by site and gender in different regions of Europe. Men and women aged 50–79 years were recruited from populat...

A. A. Ismail, S. R. Pye, W. C. Cockerill, M. Lunt… in Osteoporosis International (2002)

Article

Detection of Osteoporosis by Dual Energy X-ray Absorptiometry (DXA) of the Calcaneus: Is the WHO Criterion applicable?

E.M.B. Pacheco, E.J. Harrison, K.A. Ward, M. Lunt… in Calcified Tissue International (2002)

Article

Improving Risk Assessment: Hip Geometry, Bone Mineral Distribution and Bone Strength in Hip Fracture Cases and Controls. The EPOS Study

Hip geometry and bone mineral density (BMD) have previously been shown to relate independently to hip fracture risk. Our objective was to determine by how much hip geometric data improved the identification o...

N. J. Crabtree, H. Kroger, A. Martin, H. A. P. Pols… in Osteoporosis International (2002)

Article

A Statistical Method to Minimize Magnification Errors in Serial Vertebral Radiographs

Incident vertebral deformities are commonly defined by observed changes in height between measurements on two consecutive radiographs. However, conventional radiographs are subject to magnification, and this ...

M. Lunt, W. Gowin, O. Johnell, G. Armbrecht, D. Felsenberg… in Osteoporosis International (2001)

Article

The Effects of Lifestyle, Dietary Dairy Intake and Diabetes on Bone Density and Vertebral Deformity Prevalence: The EVOS Study

The risk of low and moderate energy fracture is related to bone mineral density (BMD). Yet it is uncertain whether the epidemiologic determinants of fracture risk are the same as for low bone density. The Eur...

M. Lunt, P. Masaryk, C. Scheidt-Nave, J. Nijs, G. Poor… in Osteoporosis International (2001)

Article

Incidence of Distal Forearm Fracture in British Men and Women

Fracture of the distal forearm is one of the most frequent osteoporotic fractures. However, there are few data concerning its incidence in Britain. The aim of this study was to determine the incidence of dist...

T. W. O’Neill, C. Cooper, J. D. Finn, M. Lunt, D. Purdie… in Osteoporosis International (2001)

Article

Prevalent Vertebral Deformity Predicts Incident Hip though not distal Forearm Fracture: Results from the European Prospective Osteoporosis Study

The presence of a vertebral deformity increases the risk of subsequent spinal deformities. The aim of this analysis was to determine whether the presence of vertebral deformity predicts incident hip and other...

A. A. Ismail, W. Cockerill, C. Cooper, J. D. Finn… in Osteoporosis International (2001)

Article

Vertebral Morphometry: Repeat Scan Precision Using the Lunar Expert-XL and the Hologic 4500A. A Study for the “WISDOM” RCT of Hormone Replacement Therapy

On radiation safety grounds there is concern about the morbidity attributable to routine radiographs of the spine for the identification of new fractures in large-scale trials of fracture prevention. However,...

N. Crabtree, J. Wright, A. Walgrove, J. Rea, L. Hanratty… in Osteoporosis International (2000)

Article

Bone Density Reduction in Various Measurement Sites in Men and Women with Osteoporotic Fractures of Spine and Hip: The European Quantitation of Osteoporosis Study

We have measured bone mineral density (BMD) using dual X-ray absorptiometry (DXA) of the spine and hip, spinal quantitative computed tomography (QCTspi), and peripheral radial quantitative computed tomography...

H. Kröger, M. Lunt, J. Reeve, J. Dequeker, J. E. Adams… in Calcified Tissue International (1999)

Article

Effects of Menstrual History and Use of Medications on Bone Mineral Density: The EVOS Study

We have previously shown considerable between-center variation in bone mineral density (BMD) in the 13 EVOS centers that performed bone densitometry on their sex- and age-stratified population samples, after ...

P. Masaryk, M. Lunt, L. Benevolenskaya, J. Cannata… in Calcified Tissue International (1998)