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Semi-mechanistic Modelling of the Analgesic Effect of Gabapentin in the Formalin-Induced Rat Model of Experimental Pain

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  1. Article

    Open Access

    Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans

    The selection of the most suitable animal species and subsequent translation of the concentration-effect relationship to humans are critical steps for accurate assessment of the pro-arrhythmic risk of candidat...

    V. F. S. Dubois, W. E. A. de Witte, S. A. G. Visser, M. Danhof… in Pharmaceutical Research (2016)

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  2. Article

    Open Access

    Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

    Clinical Trial Simulations (CTS) are a valuable tool for decision-making during drug development. However, to obtain realistic simulation scenarios, the patients included in the CTS must be representative of t...

    D. Teutonico, F. Musuamba, H. J. Maas, A. Facius, S. Yang… in Pharmaceutical Research (2015)

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  3. Article

    Open Access

    Prediction of Disease Progression, Treatment Response and Dropout in Chronic Obstructive Pulmonary Disease (COPD)

    Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), nu...

    F. T. Musuamba, D. Teutonico, H. J. Maas, A. Facius, S. Yang… in Pharmaceutical Research (2015)

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