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Article

Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans

The selection of the most suitable animal species and subsequent translation of the concentration-effect relationship to humans are critical steps for accurate assessment of the pro-arrhythmic risk of candidat...

V. F. S. Dubois, W. E. A. de Witte, S. A. G. Visser, M. Danhof… in Pharmaceutical Research (2016)