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  1. Article

    Open Access

    Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

    Clinical Trial Simulations (CTS) are a valuable tool for decision-making during drug development. However, to obtain realistic simulation scenarios, the patients included in the CTS must be representative of t...

    D. Teutonico, F. Musuamba, H. J. Maas, A. Facius, S. Yang… in Pharmaceutical Research (2015)

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  2. Article

    Open Access

    Prediction of Disease Progression, Treatment Response and Dropout in Chronic Obstructive Pulmonary Disease (COPD)

    Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), nu...

    F. T. Musuamba, D. Teutonico, H. J. Maas, A. Facius, S. Yang… in Pharmaceutical Research (2015)

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  3. No Access

    Article

    Photopatterning of a monomolecular dye film by means of scanning near-field optical microscopy

    Patterned bleaching of a photolabile monomolecular dye film by means of scanning near-field optical microscopy (SNOM) is demonstrated. After exposure, the written patterns were verified by SNOM with fluorescen...

    A. Naber, T. Dziomba, U.C. Fischer, H.-J. Maas, H. Fuchs in Applied Physics A (2000)

  4. No Access

    Article

    Synthese des (±)-Rosmarinsäuremethylesters

    Regioselective cleavage of the glycidic ester3 by BF3/ether to pyruvic acid ester4 followed by NaBH4 reduction affords the lactic acid derivative5a which in turn can be acylated by caffeoyl chloride8c to yield th...

    E. Reimann, H. -J. Maas, T. Pflug in Monatshefte für Chemie / Chemical Monthly (1997)