11 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
Naihe **g
Article
-
Article
Open AccessTime space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation
Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages ...
-
Article
Open AccessBase editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation
During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in this field, the functional significance of DNA methylation in e...
-
Article
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessA secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. A...
-
Article
Molecular architecture of lineage allocation and tissue organization in early mouse embryo
During post-implantation development of the mouse embryo, descendants of the inner cell mass in the early epiblast transit from the naive to primed pluripotent state1. Concurrently, germ layers are formed and cel...
-
Article
Open AccessAuthor Correction: Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
-
Article
Open AccessInference of differentiation time for single cell transcriptomes using cell population reference data
Single-cell RNA sequencing (scRNA-seq) is a powerful method for dissecting intercellular heterogeneity during development. Conventional trajectory analysis provides only a pseudotime of development, and often ...
-
Article
Open AccessAbnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII
The paraventricular nucleus of hypothalamus plays important roles in the regulation of energy balance and fetal growth. However, the molecular mechanisms underlying its formation and function have not been cle...
-
Article
Open AccessTRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
Generation of β-amyloid (Aβ) peptide in Alzheimer’s disease involves cleavage of amyloid precursor protein (APP) by γ-secretase, a protease known to cleave several substrates, including Notch. Finding specific...
-
Article
Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate
Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well as epigenetic regulators. Nevertheless, how neural fate commitment is ...
